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      Seminars in Thrombosis, Thrombolysis and Vascular Biology

      Cardiology

      S. Karger AG

      Thrombolysis, Coagulation, Vascular biology, Endothelium

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          Abstract

          The vascular endothelium, once believed to act solely as a mechanical barrier is, in fact, the body’s most active paracrine organ serving a vital role in vasomotion and thromboresistance. Vasoactive compounds such as prostacyclin and endothelium-derived relaxing factor maintain coronary blood flow in response to physiologic demands, while their antiplatelet effects act along with tissue plasminogen activator and heparin-like species to prevent local thrombus formation. Structural and functional endothelial abnormalities may predispose to vascular thrombosis or impair normal vasodilatory responses to increasing metabolic demands. Acquired endothelial dysfunction following coronary reperfusion, aortocoronary bypass grafting and balloon angioplasty plays a vital role in short- and long-term patient outcome. Future therapies in cardiovascular disease must consider strategies to preserve and facilitate the structural and functional integrity of the vascular endothelium.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1991
          1991
          12 November 2008
          : 78
          : 1
          : 13-22
          Affiliations
          Coronary Care Unit, Thrombosis Research Center, University of Massachusetts Medical School, Worcester, Mass., USA
          Article
          174760 Cardiology 1991;78:13–22
          10.1159/000174760
          1902398
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Original Paper

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