[The regulation of gonadal somatic cell differentiation during sex determination in mice].

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

In mammals, the gonad is composed of germ cells and somatic cells. The gonads have the potential of bidirectional differentiation before sex determination. The differentiation of somatic cells in the gonad determines the development of testis or ovary, and this process is regulated by many factors. SRY, SOX9, SOX3, SOX8, SOX10, FGF9/FGFR2, PGD2, AMH, and DMRT1 are involved in the differentiation of testis. By contrast, FOXL2, CTNNB1, RSPO1, WNT4, Follistatin, ERα/β, and BMP2 play important roles in ovary development. If these molecular regulatory networks are damaged by endogenous or exogenous factors, disorders of sex differentiation, even sex reversal, will occur. In this review, the regulation of somatic cell fate during gonad primordium formation and sex determination in mouse model was discussed.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Sheng Li Xue Bao

Title: Sheng li xue bao : [Acta physiologica Sinica]

Publisher:

ISSN: 0371-0874

ISSN (Print): 0371-0874

Publication date (Electronic): Feb 25 2020

Volume: 72

Issue: 1

Affiliations

[1 ] Department of Basic Medical Sciences, Zunyi Medical University, Zunyi 563000, China.

[2 ] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

[3 ] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. gaof@ioz.ac.cn.

[4 ] University of Chinese Academy of Sciences, Beijing 100049, China.

Article

PubMed ID: 32099981

SO-VID: 37ba377b-de8d-478a-8e66-cb84ad681a89

History

Data availability:

Comments

Comment on this article

Cited by 3

See all cited by