Dora Pinto: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: ResourcesRole: ValidationRole:
VisualizationRole: Writing - original draftRole: Writing - review & editing
Maximilian M. Sauer:
ORCID: https://orcid.org/0000-0003-0908-0775
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: ValidationRole: VisualizationRole: Writing - original draftRole:
Writing - review & editing
Nadine Czudnochowski:
ORCID: https://orcid.org/0000-0002-3146-4110
Role: Formal analysisRole: InvestigationRole: Project administrationRole: ResourcesRole:
Writing - review & editing
Jun Siong Low:
ORCID: https://orcid.org/0000-0002-1775-0778
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing
- review & editing
M. Alejandra Tortorici:
ORCID: https://orcid.org/0000-0002-2260-2577
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ValidationRole: VisualizationRole: Writing - review &
editing
Michael P. Housley: Role: InvestigationRole: Validation
Julia Noack:
ORCID: https://orcid.org/0000-0002-9113-8181
Role: Formal analysisRole: InvestigationRole: MethodologyRole: ValidationRole: Visualization
Alexandra C. Walls:
ORCID: https://orcid.org/0000-0002-9636-8330
Role: InvestigationRole: Writing - review & editing
John E. Bowen:
ORCID: https://orcid.org/0000-0003-3590-9727
Role: InvestigationRole: MethodologyRole: ValidationRole: Writing - review & editing
Barbara Guarino:
ORCID: https://orcid.org/0000-0003-3759-3252
Role: InvestigationRole: MethodologyRole: Visualization
Laura E. Rosen:
ORCID: https://orcid.org/0000-0002-8030-0219
Role: Investigation
Julia di Iulio:
ORCID: https://orcid.org/0000-0001-9343-127X
Role: Formal analysisRole: Software
Josipa Jerak:
ORCID: https://orcid.org/0000-0001-5358-5055
Role: ConceptualizationRole: InvestigationRole: ResourcesRole: Validation
Hannah Kaiser:
ORCID: https://orcid.org/0000-0002-3991-7401
Role: Investigation
Saiful Islam: Role: InvestigationRole: MethodologyRole: Validation
Nicole Sprugasci:
ORCID: https://orcid.org/0000-0003-3258-5552
Role: Investigation
Katja Culap:
ORCID: https://orcid.org/0000-0002-0956-0018
Role: Investigation
Rana Abdelnabi:
ORCID: https://orcid.org/0000-0001-9771-7312
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: ValidationRole: VisualizationRole: Writing
- original draft
Caroline Foo:
ORCID: https://orcid.org/0000-0002-6380-4917
Role: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole:
SupervisionRole: ValidationRole: Writing - review & editing
Lotte Coelmont:
ORCID: https://orcid.org/0000-0002-7888-4534
Role: ConceptualizationRole: MethodologyRole: Project administrationRole: SupervisionRole:
ValidationRole: Writing - original draft
Istvan Bartha:
ORCID: https://orcid.org/0000-0003-3360-1999
Role: Formal analysisRole: Software
Siro Bianchi:
ORCID: https://orcid.org/0000-0002-5100-8905
Role: Investigation
Chiara Silacci-Fregni: Role: Data curationRole: InvestigationRole: MethodologyRole: ResourcesRole: Validation
Jessica Bassi:
ORCID: https://orcid.org/0000-0002-4723-6892
Role: Data curationRole: Formal analysisRole: InvestigationRole: ResourcesRole: Validation
Roberta Marzi:
ORCID: https://orcid.org/0000-0001-6025-6735
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing
- review & editing
Eneida Vetti: Role: Investigation
Antonino Cassotta:
ORCID: https://orcid.org/0000-0001-8674-4294
Role: ConceptualizationRole: InvestigationRole: Methodology
Alessandro Ceschi:
ORCID: https://orcid.org/0000-0002-4308-0405
Role: InvestigationRole: ResourcesRole: Writing - review & editing
Paolo Ferrari:
ORCID: https://orcid.org/0000-0002-9619-3104
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Project administrationRole:
ValidationRole: Writing - original draftRole: Writing - review & editing
Pietro E. Cippà: Role: InvestigationRole: Project administrationRole: ResourcesRole: Supervision
Olivier Giannini:
ORCID: https://orcid.org/0000-0003-2306-0498
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: Resources
Samuele Ceruti:
ORCID: https://orcid.org/0000-0003-4146-3434
Role: VisualizationRole: Writing - review & editing
Christian Garzoni:
ORCID: https://orcid.org/0000-0002-0832-2376
Role: Resources
Agostino Riva:
ORCID: https://orcid.org/0000-0003-3171-3049
Role: Resources
Fabio Benigni:
ORCID: https://orcid.org/0000-0002-1974-5606
Role: Formal analysisRole: InvestigationRole: ResourcesRole: ValidationRole: Visualization
Elisabetta Cameroni: Role: ConceptualizationRole: InvestigationRole: Project administrationRole: Resources
Luca Piccoli: Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
ResourcesRole: SupervisionRole: Validation
Matteo S. Pizzuto: Role: ConceptualizationRole: Data curationRole: Project administrationRole: ResourcesRole:
Supervision
Megan Smithey: Role: Project administrationRole: ResourcesRole: Supervision
David Hong: Role: Project administrationRole: Resources
Amalio Telenti: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole:
ValidationRole: Visualization
Florian A. Lempp: Role: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole:
Writing - review & editing
Johan Neyts: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing - original draftRole: Writing - review & editing
Colin Havenar-Daughton: Role: ResourcesRole: Validation
Antonio Lanzavecchia: Role: Writing - original draftRole: Writing - review & editing
Federica Sallusto: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
SupervisionRole: ValidationRole: Writing - review & editing
Gyorgy Snell: Role: ConceptualizationRole: Formal analysisRole: Project administrationRole: VisualizationRole:
Writing - original draftRole: Writing - review & editing
Herbert W. Virgin: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
SupervisionRole: ValidationRole: Writing - original draftRole: Writing - review &
editing
Martina Beltramello: Role: ConceptualizationRole: Formal analysisRole: Project administrationRole: ResourcesRole:
ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review
& editing
Davide Corti: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole:
Writing - review & editing
David Veesler: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing - original draft
Journal ID (nlm-ta): Science
Journal ID (iso-abbrev): Science
Journal ID (publisher-id): science
Title:
Science (New York, N.y.)
Publisher:
American Association for the Advancement of Science
ISSN
(Print):
0036-8075
ISSN
(Electronic):
1095-9203
Publication date
(Print, pub):
03
September
2021
Publication date
(Electronic):
03
August
2021
Publication date PMC-release: 03
August
2021
Volume: 373
Issue: 6559
Pages: 1109-1116
Affiliations
[1
]Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.
[2
]Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
[3
]Vir Biotechnology, San Francisco, CA 94158, USA.
[4
]Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona,
Switzerland.
[5
]Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven,
3000 Leuven, Belgium.
[6
]Clinical Trial Unit, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.
[7
]Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences
of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.
[8
]Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091
Zurich, Switzerland.
[9
]Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland.
[10
]Department of Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
[11
]Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
[12
]Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland.
[13
]Intensive Care Unit, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.
[14
]Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900
Lugano, Switzerland.
[15
]III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital,
20157 Milan, Italy.
[16
]Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland.
[17
]UT Southwestern Medical Center, Dallas, TX 75390, USA.
[18
]Washington University School of Medicine, St. Louis, MO 63110, USA.
Author notes
[†]
These authors contributed equally to this work.
Author information
Article
Publisher ID:
abj3321
DOI: 10.1126/science.abj3321
PMC ID: 9268357
PubMed ID: 34344823
SO-VID: 37ba9895-a6c2-4f96-a016-bb15629f3620
Copyright © Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association
for the Advancement of Science. No claim to original U.S. Government Works. Distributed
under a Creative Commons Attribution License 4.0 (CC BY).
License:
This is an open-access article distributed under the terms of the
Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original work is properly cited.
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FundRef http://dx.doi.org/10.13039/100000002, National Institutes of Health;
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FundRef http://dx.doi.org/10.13039/100000015, U.S. Department of Energy;
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FundRef http://dx.doi.org/10.13039/100000057, National Institute of General Medical Sciences;
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FundRef http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
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FundRef http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
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