Greater than 90% of dogs with appendicular osteosarcoma will develop pulmonary metastasis despite the standard of care. Available treatments have limited efficacy for stage III disease. Zoledronate, a bisphosphonate, induces apoptosis of canine osteosarcoma cells and appears to modulate the tumour microenvironment.
This prospective, single institutional phase IIa trial investigated the use of single agent zoledronate in dogs with pulmonary metastases from osteosarcoma.
Zoledronate was administered once monthly, and thoracic radiographs were used to assess response.
Eleven dogs were enrolled. Stable disease was achieved in two of eight dogs available for response assessment. The median progression‐free survival was 28 days (range: 4–93 days). The median stage III‐specific survival time was 92 days. Adverse events were reported in four dogs; two dogs developed grade III or higher toxicities. Notable adverse events included conjunctivitis, fever, hypocalcaemia, and hypophosphatemia.
This single institutional phase IIa trial investigated the use of single agent zoledronate in 11 dogs with stage III osteosarcoma. Stable disease was achieved in 2 of 8 dogs available for response assessment (median progression free survival = 28 days). Adverse events were reported in 4 dogs, including conjunctivitis, fever, and hypocalcemia.