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      High-performance liquid chromatographic separation of enantiomers of unusual amino acids on a teicoplanin chiral stationary phase.

      1 , ,
      Journal of chromatography. A

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          Abstract

          A glycopeptide antibiotic, teicoplanin, was used as chiral stationary phase for the high-performance liquid chromatographic (HPLC) separation of enantiomers of more than 30 unnatural amino acids, such as phenylalanine and tyrosine analogues and analogues containing 1,2,3,4-tetrahydroisoquinoline, tetraline, 1,2,3,4-tetrahydro-2-carboline, cyclopentane, cyclohexane, cyclohexene, bicyclo[2.2.1]heptane or heptene skeletons. Excellent resolutions were achieved for most of the investigated compounds by using a hydro-organic mobile-phase system. The effects of organic modifier content, temperature and flow-rate on the resolution were investigated and the conditions of separation were optimized.

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          Author and article information

          Journal
          J Chromatogr A
          Journal of chromatography. A
          0021-9673
          0021-9673
          Jan 16 1998
          : 793
          : 2
          Affiliations
          [1 ] Department of Inorganic and Analytical Chemistry, Attila József University, Szeged, Hungary.
          Article
          10.1016/S0021-9673(97)00938-2
          9474786
          387d31e4-c9b7-4731-b381-d94c25d7d2d5
          History

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