NON-RADIOACTIVE OLIGOTYPING FOR HLA-DR1-DRw10 USING POLYMERASE CHAIN REACTION, DIGOXIGENIN-LABELLED OLIGONUCLEOTIDES AND CHEMILUMINESCENCE DETECTION

Hinzpeter, M; Albert, E.D.; Nevinny-Stickel, C; Andreas, A.

doi:10.1111/j.1744-313X.1991.tb00032.x

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NON-RADIOACTIVE OLIGOTYPING FOR HLA-DR1-DRw10 USING POLYMERASE CHAIN REACTION, DIGOXIGENIN-LABELLED OLIGONUCLEOTIDES AND CHEMILUMINESCENCE DETECTION

Author(s): C. Nevinny-Stickel , M. Hinzpeter , A. Andreas , E.D. Albert

Publication date Created: October 1991

Publication date (Print): October 1991

Journal: European Journal of Immunogenetics

Publisher: Wiley

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HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

J Todd, J Bell, H O McDevitt (1987)

Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells.