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      • Record: found
      • Abstract: found
      • Article: found

      Effect of Dietary Ascorbic Acid on Heat-Induced Eye Lens Protein Damage in Guinea Pigs

      research-article
      Author(s): , ,
      Publication date (Electronic):
      Journal: Ophthalmic Research
      Publisher: S. Karger AG
      Keywords: Ascorbic acid, Cataract, Eye lens, Protein, Heat-induced damage

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          Abstract

          The effect of large intake of dietary ascorbic acid on heat-induced eye lens protein damage has been studied. Male guinea pigs of the Hartley strain were used. Ascorbic acid was administered to the experimental animals in the drinking water. The mean daily ascorbic acid intakes for the control and experimental animals were 10 and 366 mg/kg body weight, respectively. The ascorbic acid level in the lens of the experimental animals was significantly higher than in the controls, but no differences in the content of water-soluble lens proteins were observed. When a solution of water-soluble protein was incubated at 60 ° C, insoluble aggregates were formed. The loss of water-soluble proteins from the lens of the experimental animals was significantly less than that of the controls. The results indicated that large quantities of dietary ascorbic acid were able to protect lens constituents against heat-induced damage.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1990
          Publication date (Print): 1990
          Publication date (Electronic): 10 December 2009
          Volume: 22
          Issue: 2
          Pages: 106-110
          Affiliations
          Linus Pauling Institute of Science and Medicine, Palo Alto, Calif., USA
          Article
          Publisher ID: 267008 Other ID: Ophthalmic Res 1990;22:106–110
          DOI: 10.1159/000267008
          PubMed ID: 2342780
          SO-VID: 396b48d0-bf58-4b69-9e31-1db8af654c33
          Copyright © © 1990 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 12 January 1989
          Date accepted : 17 May 1989
          Page count
          Pages: 5
          Categories
          Subject: Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Cataract,Ascorbic acid,Eye lens,Protein,Heat-induced damage
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Cataract, Ascorbic acid, Eye lens, Protein, Heat-induced damage

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