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      Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

      1 , 2 , 1 , 1 , 3
      Drug Development and Industrial Pharmacy
      Informa UK Limited

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          Mechanisms of solute release from porous hydrophilic polymers

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            A simple equation for description of solute release II. Fickian and anomalous release from swellable devices

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              DDSolver: an add-in program for modeling and comparison of drug dissolution profiles.

              In recent years, several mathematical models have been developed for analysis of drug dissolution data, and many different mathematical approaches have been proposed to assess the similarity between two drug dissolution profiles. However, until now, no computer program has been reported for simplifying the calculations involved in the modeling and comparison of dissolution profiles. The purposes of this article are: (1) to describe the development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data; (2) to establish a model library for fitting dissolution data using a nonlinear optimization method; and (3) to provide a brief review of available approaches for comparing drug dissolution profiles. DDSolver is a freely available program which is capable of performing most existing techniques for comparing drug release data, including exploratory data analysis, univariate ANOVA, ratio test procedures, the difference factor f (1), the similarity factor f (2), the Rescigno indices, the 90% confidence interval (CI) of difference method, the multivariate statistical distance method, the model-dependent method, the bootstrap f (2) method, and Chow and Ki's time series method. Sample runs of the program demonstrated that the results were satisfactory, and DDSolver could be served as a useful tool for dissolution data analysis.
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                Author and article information

                Journal
                Drug Development and Industrial Pharmacy
                Drug Development and Industrial Pharmacy
                Informa UK Limited
                0363-9045
                1520-5762
                January 05 2017
                March 04 2017
                November 28 2016
                March 04 2017
                : 43
                : 3
                : 409-420
                Affiliations
                [1 ] Department of Pharmaceutics, Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan;
                [2 ] Department of Chemistry, University of Sargodha, Sargodha, Pakistan;
                [3 ] Faculty of Pharmacy, Centre for Drug Delivery Research, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
                Article
                10.1080/03639045.2016.1257017
                3a1a08e0-9265-4f85-ae2d-2d52f2491a2e
                © 2017
                History

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