Relationship between Noradrenaline-Induced Depolarization and Contraction in Vascular Smooth Muscle

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Abstract

In strips of rabbit main pulmonary artery, full dose-response curves of noradrenaline for the mechanical and electrical responses of the vascular smooth muscle cells were obtained under normal conditions and after increasing and decreasing the membrane potential with strychnine and tetraethylammonium, respectively. The results suggest that the magnitude of the noradrenaline-induced contraction is related to the height of the membrane potential and not to the degree of depolarization produced by the adrenergic transmitter.

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Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISBN: 978-3-8055-2857-3

ISBN: 978-3-318-02028-1

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 18 September 2008

Volume: 15

Issue: 1-3

Pages: 46-54

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Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel

Article

Publisher ID: 158152 Other ID: Blood Vessels 1978;15:46–54

DOI: 10.1159/000158152

SO-VID: 3a7bf589-4fd1-4e34-b8a9-6702c190683d

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Relationship between Noradrenaline-Induced Depolarization and Contraction in Vascular Smooth Muscle

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Abstract

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Karger: Cardiovascular System

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