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      Relationship between Noradrenaline-Induced Depolarization and Contraction in Vascular Smooth Muscle

      research-article
      Journal of Vascular Research
      S. Karger AG
      Rabbit main pulmonary artery, Electrogenic contraction, Noradrenaline, Strychnine, TEA

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          Abstract

          In strips of rabbit main pulmonary artery, full dose-response curves of noradrenaline for the mechanical and electrical responses of the vascular smooth muscle cells were obtained under normal conditions and after increasing and decreasing the membrane potential with strychnine and tetraethylammonium, respectively. The results suggest that the magnitude of the noradrenaline-induced contraction is related to the height of the membrane potential and not to the degree of depolarization produced by the adrenergic transmitter.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-2857-3
          978-3-318-02028-1
          1018-1172
          1423-0135
          1978
          1978
          18 September 2008
          : 15
          : 1-3
          : 46-54
          Affiliations
          Pharmaceutical Research Department of F. Hoffmann-La Roche & Co., Ltd., Basel
          Article
          158152 Blood Vessels 1978;15:46–54
          10.1159/000158152
          3a7bf589-4fd1-4e34-b8a9-6702c190683d
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 9
          Categories
          Molecular and Cellular Aspects of Vascular Smooth Muscle in Health and Disease

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Noradrenaline,Rabbit main pulmonary artery,TEA,Electrogenic contraction,Strychnine

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