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      Inhibitory Effects of Nicorandil on Rat Mesangial Cell Proliferation via the Protein Kinase G Pathway

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          Abstract

          We investigated the effects of nicorandil, which is a hybrid between a nitrate and an ATP-sensitive potassium channel (K<sub>ATP</sub>) opener, on cultured rat mesangial cell proliferation. Nicorandil (1 µ M to 1 m M inhibited [<sup>3</sup>H]thymidine incorporation into rat mesangial cells in a concentration-dependent manner. Nicorandil (1 µ M to 1 m M) also inhibited the number of cells. Nicorandil increased cyclic guanosine 3′,5′-cyclic monophosphate accumulation in mesangial cells. A protein kinase G inhibitor, KT5823, partially eliminated the inhibition of mesangial cell proliferation by nicorandil. Methylene blue, a guanylate cyclase inhibitor, blocked the inhibitory effect of nicorandil on mesangial cell proliferation. We also examined the effects of K<sub>ATP</sub> mediators. Cromakalim, a K<sub>ATP</sub> activator, and glibenclamide, a K<sub>ATP</sub> inhibitor, had little effect on the proliferation of mesangial cells. These results suggest that the inhibitory effects of nicorandil on mesangial cell proliferation are mediated via the protein kinase G pathway.

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          Most cited references 2

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          Cyclic GMP and mechanisms of vasodilation

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            Inhibitory Effect of the Intravenous Anesthetic, Ketamine, on Rat Mesangial Cell Proliferation

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              Author and article information

              Journal
              NEF
              Nephron
              10.1159/issn.1660-8151
              Nephron
              S. Karger AG
              1660-8151
              2235-3186
              2001
              2001
              16 March 2001
              : 87
              : 3
              : 263-268
              Affiliations
              aSecond Department of Internal Medicine and bDepartment of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka, Japan
              Article
              45924 Nephron 2001;87:263–268
              10.1159/000045924
              11287762
              © 2001 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 6, References: 25, Pages: 6
              Product
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/45924
              Categories
              Original Paper

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