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      Developmental changes in exploration resemble stochastic optimization

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          Abstract

          Human development is often described as a ‘cooling off’ process, analogous to stochastic optimization algorithms that implement a gradual reduction in randomness over time. Yet there is ambiguity in how to interpret this analogy, due to a lack of concrete empirical comparisons. Using data from n = 281 participants ages 5 to 55, we show that cooling off does not only apply to the single dimension of randomness. Rather, human development resembles an optimization process of multiple learning parameters, for example, reward generalization, uncertainty-directed exploration and random temperature. Rapid changes in parameters occur during childhood, but these changes plateau and converge to efficient values in adulthood. We show that while the developmental trajectory of human parameters is strikingly similar to several stochastic optimization algorithms, there are important differences in convergence. None of the optimization algorithms tested were able to discover reliably better regions of the strategy space than adult participants on this task.

          Abstract

          Giron et al. provide empirical evidence that human development has much in common with the algorithm of ‘stochastic optimization’ widely used in machine learning, resolving ambiguities around commonly used analogies in developmental psychology.

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          Optimization by simulated annealing.

          There is a deep and useful connection between statistical mechanics (the behavior of systems with many degrees of freedom in thermal equilibrium at a finite temperature) and multivariate or combinatorial optimization (finding the minimum of a given function depending on many parameters). A detailed analogy with annealing in solids provides a framework for optimization of the properties of very large and complex systems. This connection to statistical mechanics exposes new information and provides an unfamiliar perspective on traditional optimization problems and methods.
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            Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study

            Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc patients and 92 age-/sex-matched healthy controls were recruited for the cross-sectional analysis. The longitudinal analysis comprised 30 patients with SSc associated interstitial lung disease (ILD) routinely treated with cyclophosphamide. Hsp90 was increased in SSc compared to healthy controls. Hsp90 correlated positively with C-reactive protein and negatively with pulmonary function tests: forced vital capacity and diffusing capacity for carbon monoxide (DLCO). In patients with diffuse cutaneous (dc) SSc, Hsp90 positively correlated with the modified Rodnan skin score. In SSc-ILD patients treated with cyclophosphamide, no differences in Hsp90 were found between baseline and after 1, 6, or 12 months of therapy. However, baseline Hsp90 predicts the 12-month change in DLCO. This study shows that Hsp90 plasma levels are increased in SSc patients compared to age-/sex-matched healthy controls. Elevated Hsp90 in SSc is associated with increased inflammatory activity, worse lung functions, and in dcSSc, with the extent of skin involvement. Baseline plasma Hsp90 predicts the 12-month change in DLCO in SSc-ILD patients treated with cyclophosphamide.
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              Most people are not WEIRD.

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                Author and article information

                Contributors
                charley.wu@uni-tuebingen.de
                Journal
                Nat Hum Behav
                Nat Hum Behav
                Nature Human Behaviour
                Nature Publishing Group UK (London )
                2397-3374
                17 August 2023
                17 August 2023
                2023
                : 7
                : 11
                : 1955-1967
                Affiliations
                [1 ]Human and Machine Cognition Lab, University of Tübingen, ( https://ror.org/03a1kwz48) Tübingen, Germany
                [2 ]Attention and Affect Lab, University of Tübingen, ( https://ror.org/03a1kwz48) Tübingen, Germany
                [3 ]Center for Adaptive Rationality, Max Planck Institute for Human Development, ( https://ror.org/02pp7px91) Berlin, Germany
                [4 ]GRID grid.517801.a, Max Planck UCL Centre for Computational Psychiatry and Ageing Research, ; Berlin, Germany
                [5 ]MPRG Computational Principles of Intelligence, Max Planck Institute for Biological Cybernetics, ( https://ror.org/026nmvv73) Tübingen, Germany
                [6 ]Department of Psychology, University of Amsterdam, ( https://ror.org/04dkp9463) Amsterdam, the Netherlands
                [7 ]Amsterdam Brain and Cognition, University of Amsterdam, ( https://ror.org/04dkp9463) Amsterdam, the Netherlands
                [8 ]MPRG iSearch, Max Planck Institute for Human Development, ( https://ror.org/02pp7px91) Berlin, Germany
                [9 ]School of Social Sciences and Technology, Technical University Munich, ( https://ror.org/02kkvpp62) Munich, Germany
                [10 ]Central European University, ( https://ror.org/02zx40v98) Vienna, Austria
                [11 ]Institute for Mind, Brain and Behavior, Health and Medical University, Potsdam, Germany
                Author information
                http://orcid.org/0000-0002-2067-9781
                http://orcid.org/0000-0003-3088-0371
                http://orcid.org/0000-0002-0839-1929
                http://orcid.org/0000-0002-9326-400X
                http://orcid.org/0000-0002-2215-572X
                Article
                1662
                10.1038/s41562-023-01662-1
                10663152
                37591981
                3c2f4dc0-01a0-4c0c-973b-d6be0046b673
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 11 November 2022
                : 21 June 2023
                Funding
                Funded by: FundRef https://doi.org/10.13039/501100002347, Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research);
                Award ID: FKZ: 01IS18039A
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100001659, Deutsche Forschungsgemeinschaft (German Research Foundation);
                Award ID: EXC2064/1–390727645
                Award Recipient :
                Categories
                Article
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                © Springer Nature Limited 2023

                human behaviour,development studies,computational science

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