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      The Chern-Simons current in systems of DNA-RNA transcriptions

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          Abstract

          A Chern-Simons current, coming from ghost and anti-ghost fields of supersymmetry theory, can be used to define a spectrum of gene expression in new time series data where a spinor field, as alternative representation of a gene, is adopted instead of using the standard alphabet sequence of bases \(A, T, C, G, U\). After a general discussion on the use of supersymmetry in biological systems, we give examples of the use of supersymmetry for living organism, discuss the codon and anti-codon ghost fields and develop an algebraic construction for the trash DNA, the DNA area which does not seem active in biological systems. As a general result, all hidden states of codon can be computed by Chern-Simons 3 forms. Finally, we plot a time series of genetic variations of viral glycoprotein gene and host T-cell receptor gene by using a gene tensor correlation network related to the Chern-Simons current. An empirical analysis of genetic shift, in host cell receptor genes with separated cluster of gene and genetic drift in viral gene, is obtained by using a tensor correlation plot over time series data derived as the empirical mode decomposition of Chern-Simons current.

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          2 + 1 dimensional gravity as an exactly soluble system

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            Feynman diagrams for the Yang-Mills field

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              Structural basis for double-stranded RNA processing by Dicer.

              The specialized ribonuclease Dicer initiates RNA interference by cleaving double-stranded RNA (dsRNA) substrates into small fragments about 25 nucleotides in length. In the crystal structure of an intact Dicer enzyme, the PAZ domain, a module that binds the end of dsRNA, is separated from the two catalytic ribonuclease III (RNase III) domains by a flat, positively charged surface. The 65 angstrom distance between the PAZ and RNase III domains matches the length spanned by 25 base pairs of RNA. Thus, Dicer itself is a molecular ruler that recognizes dsRNA and cleaves a specified distance from the helical end.
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                Author and article information

                Journal
                24 December 2017
                Article
                10.1002/andp.201700271
                1802.00314
                3c9f4ddf-fc97-4ddf-8299-49f0ac739a3b

                http://arxiv.org/licenses/nonexclusive-distrib/1.0/

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                Custom metadata
                45 pages, 30 figures, 2 tables
                physics.gen-ph

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