In high HIV burden settings, maximizing the coverage of prevention strategies is critical
to achieving epidemic control. However, little is known about the reach and impact
of these in some communities. We undertook a cross sectional community survey in the
adjacent Greater Edendale and Vulindlela areas in the uMgungundlovu district, KwaZulu-Natal,
South Africa. Using a multistage cluster sampling method, we randomly selected enumeration
areas, households and individuals. One household member (15–49 years) selected at
random was invited for survey participation. Following consent questionnaires were
administered to obtain socio-demographic, psycho-social, behavioural information and
exposure to HIV prevention and treatment programmes. Clinical samples were collected
for laboratory measurements. Statistical analyses were performed accounting for multilevel
sampling and weighted to represent the population. Multivariable logistic regression
model assessed factors associated with HIV infection. Between June 11, 2014 to June
22, 2015, we enrolled 9812 individuals. The population-weighted HIV prevalence was
36·3% (95% confidence interval (CI) 34·8–37·8, 3969 of 9812); 44·1% (42·3–45·9, 2955
of 6265) in women and 28·0% (25·9–30·1, 1014 of 3547) in men (p<0·0001). HIV prevalence
in women 15–24 years was 22·3% (20·2–24·4, 567 of 2955) compared to 7·6% (6·0–9·3,
124 of 1024) (p<0·0001) in men of the same age. Prevalence peaked at 66·4% (61·7–71·2,
517 of 760) in women 35–39 years and 59·6% (53·0–66·3, 183 of 320) in men 40–44 years.
Consistent condom use in the last 12 months was 26·5% (24·1–28·8, 593 of 2356) in
men and 22·7% (20·9–24·4, 994 of 4350) in women, (p=0·0033); 35·7% (33·4–37·9, 1695
of 5447) of women’s male partner and 31·9% (29·5–34·3, 1102 of 3547) of men were medically
circumcised (MMC), (p<0·0001), whilst 45·6% (42·9–48·2, 1251 of 2955) of women and
36·7% (32·3–41·2, 341 of 1014) of men reported antiretroviral therapy (ART) use (p=0·0003).
HIV viral suppression was achieved in 54·8% (52·0–57·5, 1574 of 2955) of women and
41·9% (37·1–46·7, 401 of 1014) of men (p<0·0001) and 87·2% (84·6–89·8, 1086 of 1251)
of women and 83·9% (78·5–89·3, 284 of 341) (p=0·3670) men on ART. Age, incomplete
secondary schooling, being single, having more than one lifetime sex partners (women),
sexually transmitted infections and not being medically circumcised were associated
with HIV positive status. The HIV burden in specific age groups, the suboptimal differential
coverage, and uptake of HIV prevention strategies justifies a location-based approach
to surveillance with finer disaggregation by age and sex. Intensified and customised
approaches to seek, identify, and link individuals to HIV services are crucial to
achieving epidemic control in this community.