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      Is Open Access

      Retro-Inverso Carbohydrate Mimetic Peptides with Annexin1-Binding Selectivity, Are Stable In Vivo, and Target Tumor Vasculature

      research-article
      Author(s): , , , , 1 , *
      Editor(s):
      Publication date (Electronic):
      Journal: PLoS ONE
      Publisher: Public Library of Science

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          Abstract

          Previous research suggests that carbohydrate mimetic peptide IF7 (IFLLWQR) has an excellent targeting property to annexin1 (Anxa1), a specific marker on the tumor endothelium. However, IF7 is susceptible to proteolysis and has a poor stability in vivo. We prepared a D-amino acid, reverse sequence peptide of IF7, designated RIF7, to confer protease resistance while retaining bioactivity. Experimental results indicate that RIF7 had significantly increased stability and an increased receptor binding affinity than IF7, and this new moiety may represent a clinically relevant vehicle for anticancer drugs.

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          Most cited references26

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          Drug delivery and targeting.

          R. Langer (1998)
          When a pharmaceutical agent is encapsulated within, or attached to, a polymer or lipid, drug safety and efficacy can be greatly improved and new therapies are possible. This has provided the impetus for active study of the design of degradable materials, intelligent delivery systems and approaches for delivery through different portals in the body.
          Article 0 comments Cited 178 times – based on 0 reviews     Review now
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            Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy.

            Yan-Hui Li, E Testa, Karolina Krasinska … (2004)
            The molecular complexity of tissues and the inaccessibility of most cells within a tissue limit the discovery of key targets for tissue-specific delivery of therapeutic and imaging agents in vivo. Here, we describe a hypothesis-driven, systems biology approach to identifying a small subset of proteins induced at the tissue-blood interface that are inherently accessible to antibodies injected intravenously. We use subcellular fractionation, subtractive proteomics and bioinformatics to identify endothelial cell surface proteins exhibiting restricted tissue distribution and apparent tissue modulation. Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively. Radio-immunotherapy to annexin A1 destroys tumours and increases animal survival. This analytical strategy can map tissue- and disease-specific expression of endothelial cell surface proteins to uncover novel accessible targets useful for imaging and therapy.
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              Protease inhibitors: current status and future prospects.

              Donmienne Leung, Giovanni Abbenante, David Fairlie (2000)
              Article 0 comments Cited 57 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Joseph J. Barchi: Role: Editor
                Journal
                Journal ID (nlm-ta): PLoS One
                Journal ID (iso-abbrev): PLoS ONE
                Journal ID (publisher-id): plos
                Journal ID (pmc): plosone
                Title: PLoS ONE
                Publisher: Public Library of Science (San Francisco, USA )
                ISSN (Electronic): 1932-6203
                Publication date Collection: 2013
                Publication date (Electronic): 2 December 2013
                Volume: 8
                Issue: 12
                Electronic Location Identifier: e80390
                Affiliations
                [1 ]Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
                National Cancer Institute at Frederick, United States of America
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Conceived and designed the experiments: XYS. Performed the experiments: XYC. Analyzed the data: YZC ZYF. Contributed reagents/materials/analysis tools: ZYF XLF. Wrote the paper: XYC.

                Article
                Publisher ID: PONE-D-13-22931
                DOI: 10.1371/journal.pone.0080390
                PMC ID: 3846562
                PubMed ID: 24312470
                SO-VID: 3f137b1e-2512-4175-9840-6f4e827edf10
                Copyright statement: Copyright @ 2013
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                Date received : 3 June 2013
                Date accepted : 2 October 2013
                Page count
                Pages: 8
                Funding
                The work was sponsored by National Nature Science Foundation of China (81273459), Shanghai Rising-Star Program (10QA1400800), National Basic Research Program of China (2013CB932500) and National Science and Technology Major Project (2012ZX09304004). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Subject: Research Article

                ScienceOpen disciplines: Uncategorized
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                ScienceOpen disciplines: Uncategorized

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