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      Etiology and Measurement of Peri-Implant Crestal Bone Loss (CBL)

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          Abstract

          The etiology of peri-implant crestal bone loss is today better understood and certain factors proposed in the past have turned out to not be of concern. Regardless, the incidence of crestal bone loss remains higher than necessary and this paper reviews current theory on the etiology with a special emphasis on traditional and innovative methods to assess the level of crestal bone around dental implants that will enable greater sensitivity and specificity and significantly reduce variability in bone loss measurement.

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          Most cited references116

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          Stress and Health: Psychological, Behavioral, and Biological Determinants

          Stressors have a major influence upon mood, our sense of well-being, behavior, and health. Acute stress responses in young, healthy individuals may be adaptive and typically do not impose a health burden. However, if the threat is unremitting, particularly in older or unhealthy individuals, the long-term effects of stressors can damage health. The relationship between psychosocial stressors and disease is affected by the nature, number, and persistence of the stressors as well as by the individual's biological vulnerability (i.e., genetics, constitutional factors), psychosocial resources, and learned patterns of coping. Psychosocial interventions have proven useful for treating stress-related disorders and may influence the course of chronic diseases.
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            A Brain Tumor Molecular Imaging Strategy Using A New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle

            The vexing difficulty in delineating brain tumor margins represents a major obstacle toward better outcome of brain tumor patients. Current imaging methods are often limited by inadequate sensitivity, specificity, and spatial resolution. Here we show that a unique triple-modality Magnetic resonance imaging - Photoacoustic imaging – surface enhanced Raman scattering (SERS) nanoparticle (MPR) can accurately help delineate the margins of brain tumors in living mice both pre- and intra-operatively. The MPRs were detected by all three modalities with at least picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to specific MPR accumulation and retention by the tumors, allowing for non-invasive tumor delineation by all three modalities through the intact skull. Raman imaging allowed guidance of intra-operative tumor resection, and histological correlation validated that Raman imaging is accurately delineating brain tumor margins. This novel triple-modality nanoparticle approach holds promise to enable more accurate brain tumor imaging and resection.
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              Universal back-projection algorithm for photoacoustic computed tomography

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                Author and article information

                Journal
                J Clin Med
                J Clin Med
                jcm
                Journal of Clinical Medicine
                MDPI
                2077-0383
                01 February 2019
                February 2019
                : 8
                : 2
                : 166
                Affiliations
                [1 ]Department of Prosthodontics, Dental Science Faculty, University of Bordeaux, 33000 Bordeaux, France; Adrien.naveau@ 123456laposte.net
                [2 ]Dental and Periodontal Rehabilitation Unit, Saint Andre Hospital, Bordeaux University Hospital, 33000 Bordeaux, France
                [3 ]Department of Oral Implants, Kyushu Dental University, Kitakyushu, Fukuoka 803-8580, Japan; k.shinmyouzu@ 123456spice.ocn.ne.jp
                [4 ]Tanpopo Dental Clinic, Nerima ward, Tokyo 178-0062, Japan
                [5 ]Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA; cam081@ 123456eng.ucsd.edu (C.M.); jjokerst@ 123456eng.ucsd.edu (J.J.)
                [6 ]Faculty of Dentistry, University of Toronto, Toronto M5G1G6, ON M5G 1G6, Canada; Limor.Avivi-Arber@ 123456dentistry.utoronto.ca
                [7 ]Materials Science Program, University of California San Diego, La Jolla, CA 92093, USA
                [8 ]Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA
                [9 ]Private practice, Koka Dental Clinic, San Diego, CA 92111, USA
                [10 ]Advanced Prosthodontics, Loma Linda University School of Dentistry, Loma Linda, CA 92350, USA
                [11 ]Advanced Prosthodontics, University of California Los Angeles School of Dentistry, Los Angeles, CA 90095, USA
                Author notes
                [* ]Correspondence: skoka66@ 123456gmail.com ; Tel.: +1-858-268-5020
                Author information
                https://orcid.org/0000-0002-1809-5955
                https://orcid.org/0000-0002-0567-6101
                Article
                jcm-08-00166
                10.3390/jcm8020166
                6406263
                30717189
                3f8a77a2-c95f-4606-bc0a-3576055a8442
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 31 December 2018
                : 24 January 2019
                Categories
                Review

                crestal bone loss,osseosufficiency,osseoseparation,peri-implantitis,photoacoustic ultrasound,brain–bone axis,foreign body reaction,overloading,radiography,cbct (cone beam computerized tomography)

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