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Abstract
Modular, fully synthetic routes to structurally complex natural products provide useful
avenues to access chemical diversity. Herein we report a concise route to virginiamycin
M2, a member of the group A streptogramin class of natural products that inhibits
bacterial protein synthesis. Our approach features a longest linear sequence of six
steps from 7 simple building blocks, and is the shortest and highest yielding synthesis
of any member of the streptogramin class reported to date. We believe this route will
enable access to unexplored structural diversity and may serve as a useful tool to
improve the therapeutic potential of the streptogramin class of antibiotics.