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      Endothelin-1 peptides and IL-5 synergistically increase the expression of IL-13 in eosinophils.

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          Abstract

          The 21-amino acid-length endothelin-1 (ET-1)(1-21) and its novel derivative, 31 amino acid-length ET-1(1-31), have proinflammatory properties and induce significant eosinophil migration mediated by an increase in the local levels of eotaxin and IL-5. We have analyzed by reverse transcription polymerase chain reaction and enzyme immunoassay the effects of ETs on the expression of IL-13 mRNA and protein in eosinophils with or without cell priming with IL-5. The expression of the ETA receptor (ETAR) and its membrane localization were detected in the eosinophils, whereas the ETB receptor was undetectable. ET peptides synergistically increased the expression of IL-13 in eosinophils after priming with IL-5, and the increase was blocked by the ETAR antagonist BQ123, though these peptides did not directly influence the expression. These results may explain the presence of eosinophilia in the airways' epithelium of patients suffering from asthma, along with an increase in immunoreactive ETs.

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          Author and article information

          Journal
          Biochem. Biophys. Res. Commun.
          Biochemical and biophysical research communications
          Elsevier BV
          0006-291X
          0006-291X
          Mar 19 2004
          : 315
          : 4
          Affiliations
          [1 ] Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770-8503, Japan.
          Article
          S0006291X04002293
          10.1016/j.bbrc.2004.01.168
          14985080
          40d98dd8-fa51-424f-a5b7-9514a6dee942

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