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      A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.

      Science (New York, N.Y.)
      Acquired Immunodeficiency Syndrome, immunology, microbiology, Amino Acid Sequence, Animals, Antibodies, Viral, Antibody Formation, Antigens, Viral, Deltaretrovirus, genetics, Electrophoresis, Polyacrylamide Gel, Haplorhini, Humans, Male, Molecular Weight, Repetitive Sequences, Nucleic Acid

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          Abstract

          A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.

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