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      The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

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      Nature cell biology

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          Abstract

          Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour’s underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.

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          Author and article information

          Journal
          100890575
          21417
          Nat Cell Biol
          Nat. Cell Biol.
          Nature cell biology
          1465-7392
          1476-4679
          23 October 2018
          August 2014
          07 November 2018
          : 16
          : 8
          : 717-727
          Affiliations
          Sandra S. McAllister is in the Hematology Division, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA; the Broad Institute of Harvard and MIT, Cambridge, Massachusetts, 02142, USA; and the Harvard Stem Cell Institute, Cambridge, Massachusetts, 02138, USA. Robert A. Weinberg is at the Whitehead Institute for Biomedical Research, the Department of Biology, Massachusetts Institute of Technology, and the MIT Ludwig Center for Molecular Oncology, Cambridge, Massachusetts, 02142, USA.
          Article
          PMC6220424 PMC6220424 6220424 nihpa993924
          10.1038/ncb3015
          6220424
          25082194
          41353faa-70b6-4bf1-a066-6c5fd77ec76a
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