Nanoscale reorganisation of synaptic proteins in Alzheimer&apos;s disease.

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Abstract

Synaptic strength depends strongly on the subsynaptic organisation of presynaptic transmitter release and postsynaptic receptor densities, and their alterations are expected to underlie pathologies. Although synaptic dysfunctions are common pathogenic traits of Alzheimer's disease (AD), it remains unknown whether synaptic protein nano-organisation is altered in AD. Here, we systematically characterised the alterations in the subsynaptic organisation in cellular and mouse models of AD.

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Journal

Journal ID (iso-abbrev): Neuropathol Appl Neurobiol

Title: Neuropathology and applied neurobiology

Publisher: Wiley

ISSN (Electronic): 1365-2990

ISSN (Print): 0305-1846

Publication date (Electronic): Aug 2023

Volume: 49

Issue: 4

Affiliations

[1 ] Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Ministry of Education Key Laboratory for Membrane-less Organelles and Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

[2 ] Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China.

[3 ] Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Sciences and Technology of China, Hefei, China.

[4 ] Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, China.

[5 ] Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, China.

Article

DOI: 10.1111/nan.12924

PubMed ID: 37461203

SO-VID: 413ca674-99ac-48e1-a9ce-a5214f383d55

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Keywords: super-resolution microscopy,Alzheimer's disease,amyloid-β,stochastic optical reconstruction microscopy,synaptic nanodomain architecture

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Keywords: super-resolution microscopy, Alzheimer's disease, amyloid-β, stochastic optical reconstruction microscopy, synaptic nanodomain architecture

Nanoscale reorganisation of synaptic proteins in Alzheimer's disease.

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Alternative approaches to Alzheimer's Disease

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