Correlation of trans fatty acids with the severity of coronary artery disease lesions

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Abstract

Background

Nutritional choices, which include the source of dietary fatty acids (FA), have an important significant impact on coronary artery disease (CAD). We aimed to determine on patients with CAD the relationships between Trans fatty acids (Trans FA) and different CAD associated parameters such as inflammatory and oxidative stress parameters in addition to Gensini score as a vascular severity index.

Methods

Fatty acid profiles were established by gas chromatography from 111 CAD patients compared to 120 age-matched control group. Lipid peroxidation biomarkers, oxidative stress, inflammatory parameters and Gensini score were studied.

Results

Our study showed a significant decrease of the antioxidant parameters levels such as erythrocyte glutathione peroxydase (GPx) and superoxide dismutase (SOD) activities, plasma antioxidant status (FRAP) and thiol (SH) groups in CAD patients. On the other hand, catalase activity, conjugated dienes and malondialdehyde were increased. Plasmatic and erythrocyte Trans FA were also increased in CAD patients compared to controls. Furthermore, divergent associations of these Trans FA accumulations were observed with low-density lipoprotein-cholesterol/ high-density lipoprotein-cholesterol (LDL-C/HDL-C) ratio, Apolipoprotein B (ApoB), lipid peroxidation parameters, high-sensitivity C Reactive Protein (hs-CRP), Interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and Gensini score. Especially, elaidic acid (C18:1 trans 9), trans C18:2 isomers and trans 11 eicosanoic acid are correlated with these parameters. Trans FA are also associated with oxidative stress, confirmed by a positive correlation between C20:1 trans 11 and GPx in erythrocytes.

Conclusions

High level of Trans FA was highly associated with the induction of inflammation, oxidative stress and lipoperoxidation which appear to be based on the vascular severity and might be of interest to assess the stage and progression of atherosclerosis. The measurement of these Trans FA would be of great value for the screening of lipid metabolism disorders in CAD patients.

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Most cited references 39

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O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH.. SODs inhibit such HO. production by scavengingO2-, but Cu, ZnSODs, by virtue of a nonspecific peroxidase activity, may peroxidize spin trapping agents and thus give the appearance of catalyzing OH. production from H2O2. There is a glycosylated, tetrameric Cu, ZnSOD in the extracellular space that binds to acidic glycosamino-glycans. It minimizes the reaction of O2- with NO. E. coli, and other gram negative microorganisms, contain a periplasmic Cu, ZnSOD that may serve to protect against extracellular O2-. Mn(III) complexes of multidentate macrocyclic nitrogenous ligands catalyze the dismutation of O2- and are being explored as potential pharmaceutical agents. SOD-null mutants have been prepared to reveal the biological effects of O2-. SodA, sodB E. coli exhibit dioxygen-dependent auxotrophies and enhanced mutagenesis, reflecting O2(-)-sensitive biosynthetic pathways and DNA damage. Yeast, lacking either Cu, ZnSOD or MnSOD, are oxygen intolerant, and the double mutant was hypermutable and defective in sporulation and exhibited requirements for methionine and lysine. A Cu, ZnSOD-null Drosophila exhibited a shortened lifespan.

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Author and article information

Contributors

Samia Hadj Ahmed: +21655 277 704 , hjsamia@yahoo.fr

Wafa Kharroubi: wafa.kharroubi@hotmail.com

Nadia Kaoubaa: nba_ko@yahoo.fr

Amira Zarrouk: zarroukamira@gmail.com

Fathi Batbout: fethi.batbout@rns.tn

Habib Gamra: hgamra@rns.tn

Mohamed Fadhel Najjar: najjar.fadhel@rns.tn

Gérard Lizard: gerard.lizard@u-bourgogne.fr

Isabelle Hininger-Favier: Isabelle.Hininger@univ-grenoble-alpes.fr

Mohamed Hammami: mohamed.hammami@fmm.rnu.tn

Journal

Journal ID (nlm-ta): Lipids Health Dis

Journal ID (iso-abbrev): Lipids Health Dis

Title: Lipids in Health and Disease

Publisher: BioMed Central (London )

ISSN (Electronic): 1476-511X

Publication date (Electronic): 15 March 2018

Publication date PMC-release: 15 March 2018

Publication date Collection: 2018

Volume: 17

Electronic Location Identifier: 52

Affiliations

[1 ]ISNI 0000 0004 0593 5040, GRID grid.411838.7, Research Laboratory LR12ES05 LR-NAFS ‘Nutrition - Functional Food & Vascular Health’ Faculty of Medicine, , University of Monastir, ; Avicene st, 5019 Monastir, Tunisia

[2 ]GRID grid.420157.5, Department of Cardiology, , CHU Fattouma Bourguiba, ; Monastir, Tunisia

[3 ]GRID grid.420157.5, Department of Biochemistry, , CHU Fattouma Bourguiba, ; Monastir, Tunisia

[4 ]ISNI 0000 0001 2298 9313, GRID grid.5613.1, Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA 7270 / INSERM, , University of Bourgogne Franche-Comté, ; Dijon, France

[5 ]GRID grid.450307.5, Laboratory of Fundamental and Applied Bioenergetic, INSERM, , Grenoble Alpes University, ; F-38041 Grenoble, France

Article

Publisher ID: 699

DOI: 10.1186/s12944-018-0699-3

PMC ID: 5856295

PubMed ID: 29544473

SO-VID: 414ba69c-1e40-4d9a-8151-27a5e3f60fe2

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 15 November 2017

Date accepted : 7 March 2018

Custom metadata

ScienceOpen disciplines: Biochemistry

Keywords: elaidic acid,trans c18:2 isomers,oxidative stress,lipid peroxidation,coronary artery disease

Data availability:

ScienceOpen disciplines: Biochemistry

Keywords: elaidic acid, trans c18:2 isomers, oxidative stress, lipid peroxidation, coronary artery disease

Correlation of trans fatty acids with the severity of coronary artery disease lesions

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Abstract

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Stress signalling in stem cells

Most cited references 39

Superoxide radical and superoxide dismutases.

CD36 is a receptor for oxidized low density lipoprotein.

Lipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the blood.

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