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      Analgesic and anti-inflammatory effects of aqueous extract of leaves of Pentatropis capensis Linn. f. (Bullock)

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          Abstract

          Background:

          Herbal analgesic and anti-inflammatory remedies are preferred much because of lesser side effects and also a lower tendency for habit formation. Pentatropis capensis is such an analgesic and anti-inflammatory drug which is popular among folklore remedies for various injuries and inflammatory problems. It is called by the name of Kākanāsikā in Ayurvedic works. This study was designed to investigate the analgesic, and anti-inflammatory effects of aqueous extract of P. capensis leaves (AEPC) in rats.

          Materials and Methods:

          AEPC was assessed for Analgesic effect through radiant heat tail-flick model and anti-inflammatory effect through carrageenan-induced paw edema model on Wistar strain of albino rats.

          Results:

          Pentatropis capensis leaves aqueous extract showed significant ( P < 0.001) increase in the duration of latency of tail flick response at the dose levels of 450 mg/kg, p.o. as compared to the control group. Similarly, the similar dose level produced significant ( P < 0.01) anti-inflammatory effect against acute paw edema after 3 h of carrageenan induction when compared to the control group.

          Conclusion:

          The observed effects were comparable with the standard drug-treated group thus demonstrating effective central analgesic and acute anti-inflammatory potentials of the P. capensis leaves aqueous extract and the observations substantiate its folklore use as an analgesic and anti-inflammatory.

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          Most cited references14

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          Biphasic development of carrageenin edema in rats.

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            Mediators of the inflammation induced in the rat paw by carrageenin.

            1. The time course of oedema formation in rats caused by injection of carrageenin into the paw was followed for 5.5 hours. Intact or adrenalectomized rats which had previously been injected with ellagic acid or saliva to reduce considerably the concentration of blood kininogens, or with methysergide to antagonize 5-hydroxytryptamine (5-HT) showed a reduced inflammatory response. It was concluded that kinins and 5-HT contributed significantly to oedema formation during this period.2. Mepyramine alone had no effect on oedema formation, but in combination with ellagic acid treatment, with or without methysergide, it caused a reduction suggesting that histamine played a minor role in oedema formation during the first 3 hours.3. Vascular permeability studies indicated that injection of ellagic acid did not interfere with the normal responses in skin to intradermal injections of histamine, 5-HT, bradykinin or compound 48/80. Mepyramine and methysergide, at the doses used in the carrageenin experiments, completely antagonized histamine and 5-HT, respectively, and did not affect the skin responses of bradykinin.4. Treatment in vivo with ellagic acid or rat saliva was equally effective in reducing plasma kininogen concentrations by an amount equivalent to more than 10 times the quantity of substrate 1 measured by Gautvik & Rugstad (1967).5. Rat saliva, but not ellagic acid, lowered complement levels by approximately 20%.
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              Indian Medicinal Plant – An Illustrated Dictionary

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                Author and article information

                Journal
                Anc Sci Life
                Anc Sci Life
                ASL
                Ancient Science of Life
                Medknow Publications & Media Pvt Ltd (India )
                0257-7941
                2249-9547
                Oct-Dec 2014
                : 34
                : 2
                : 64-67
                Affiliations
                [1]Department of Dravyaguna, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
                [1 ]Department of Pharmacology Laboratory, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
                Author notes
                Address for correspondence: Mr. Saikat Chowdhury, Department of Dravyaguna, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar - 361 008, Gujarat, India. E-mail: saikatchowdhurygau@ 123456yahoo.com
                Article
                ASL-34-64
                10.4103/0257-7941.153457
                4389394
                25861138
                419c40e6-89a2-4480-b685-36b432a501bb
                Copyright: © Ancient Science of Life

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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                Original Article

                Life sciences
                carrageenan,paw edema,pentatropis capensis,plethysmograph,tail flick response
                Life sciences
                carrageenan, paw edema, pentatropis capensis, plethysmograph, tail flick response

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