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      Innovation: Metabolomics: the apogee of the omics trilogy.

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          Abstract

          Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which has thereby enabled systems-level analyses. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and are shaping our understanding of cell biology, physiology and medicine.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Mar 22 2012
          : 13
          : 4
          Affiliations
          [1 ] Department of Chemistry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. gjpattij@wustl.edu
          Article
          nrm3314 NIHMS467125
          10.1038/nrm3314
          3682684
          22436749
          424e35ee-a444-4447-a5e5-3e6b1b18b5c6
          History

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