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      Role of oxidized low density lipoprotein in atherogenesis.

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          Abstract

          Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.

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          Author and article information

          Journal
          J Clin Invest
          The Journal of clinical investigation
          American Society for Clinical Investigation
          0021-9738
          0021-9738
          Dec 1991
          : 88
          : 6
          Affiliations
          [1 ] Department of Medicine, University of California, San Diego, La Jolla 92093.
          Article
          10.1172/JCI115499
          295745
          1752940
          42fa18f3-9807-425f-a80b-36ef1926cfde
          History

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