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The language of histone crosstalk.

Author(s): Edwin Smith, Ali Shilatifard, Julia Shin-Jung Lee

Publication date: 2010-09-03

Journal: Cell

Keywords: Chromatin, metabolism, Histone Code, Histones, Phosphorylation, Protein Processing, Post-Translational, Transcription, Genetic

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Abstract

It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code. Copyright 2010 Elsevier Inc. All rights reserved.

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PubMed ID:: 20813257

PMC ID:: 3711869

DOI:: 10.1016/j.cell.2010.08.011

ScienceOpen disciplines: Chemistry

Keywords: Chromatin,metabolism,Histone Code,Histones,Phosphorylation,Protein Processing, Post-Translational,Transcription, Genetic

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ScienceOpen disciplines: Chemistry

Keywords: Chromatin, metabolism, Histone Code, Histones, Phosphorylation, Protein Processing, Post-Translational, Transcription, Genetic

The language of histone crosstalk.

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