Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Indocyanine green was repurposed as iron theranostics for simultaneous detection and treatment of iron-overload disorders.

Abstract

Precise and noninvasive theranostic methods to quantify and deplete focal iron are of crucial importance for iron-overload disorders. Here, we developed an indocyanine green (ICG)–based imaging platform to reveal Fe ³⁺ in vitro and in vivo. The high sensitivity and specificity of ICG-Fe interaction facilitated MR images with a marked correlation between T ₁ signal intensity ratio ( T ₁SIR) changes and Fe ³⁺ concentration in rodent models and humans. On the basis of these findings, a rational design for coordination-driven self-assembly ICG-Lecithin (ICG/Leci) was proposed to determine Fe ³⁺. The enhancement of photoacoustic signal at 890 nm with increasing Fe ³⁺ concentration showed an over 600% higher linear slope than that of T ₁SIR changes in animal models. ICG/Leci also promoted a 100% increase in iron depletion in the liver compared with deferoxamine. The high MR sensitivity and superior photoacoustic contrast, combined with enhanced iron depletion, demonstrate that ICG/Leci is a promising theranostic agent for simultaneous detection and treatment of iron-overload disorders.

Related collections

Most cited references 60

Record: found
Abstract: found
Article: not found

Iron and cancer: more ore to be mined.

Suzy Torti, Frank Torti (2013)

Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also has the capacity to engage in redox cycling and free radical formation. Therefore, iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumour cell survival. Signalling through hypoxia-inducible factor (HIF) and WNT pathways may contribute to altered iron metabolism in cancer. Targeting iron metabolic pathways may provide new tools for cancer prognosis and therapy.

0 comments Cited 544 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Nanoparticles in photodynamic therapy.

Sasidharan Lucky, Khee-Chee Soo, Yong Zhang (2015)

0 comments Cited 520 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Physiological parameters in laboratory animals and humans.

B Davies, T. Morris (1993)

0 comments Cited 300 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Huirong Lin:

ORCID: https://orcid.org/0000-0002-0798-8280

Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Yu Zhou: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Validation

Jiaming Wang:

ORCID: https://orcid.org/0000-0001-7881-7158

Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: ValidationRole: VisualizationRole: Writing - review & editing

Huimeng Wang: Role: InvestigationRole: VisualizationRole: Writing - original draft

Tianhong Yao:

ORCID: https://orcid.org/0000-0003-1615-0946

Role: Formal analysisRole: InvestigationRole: Validation

Hu Chen:

ORCID: https://orcid.org/0000-0003-4860-6223

Role: Formal analysisRole: InvestigationRole: MethodologyRole: Validation

Yang Zhang:

ORCID: https://orcid.org/0000-0002-3476-8937

Role: MethodologyRole: ValidationRole: Visualization

En Ren:

ORCID: https://orcid.org/0000-0002-4976-5050

Role: Formal analysisRole: MethodologyRole: SoftwareRole: Validation

Lai Jiang: Role: Writing - review & editing

Chengchao Chu:

ORCID: https://orcid.org/0000-0002-1694-9363

Role: MethodologyRole: Visualization

Xiaoyuan Chen:

ORCID: https://orcid.org/0000-0002-9622-0870

Role: Writing - review & editing

Jingsong Mao:

ORCID: https://orcid.org/0000-0002-9973-5263

Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Fudi Wang:

ORCID: https://orcid.org/0000-0001-8730-0003

Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: Supervision

Gang Liu:

ORCID: https://orcid.org/0000-0003-2613-7286

Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Journal

Journal ID (nlm-ta): Sci Adv

Journal ID (iso-abbrev): Sci Adv

Journal ID (publisher-id): sciadv

Journal ID (hwp): advances

Title: Science Advances

Publisher: American Association for the Advancement of Science

ISSN (Electronic): 2375-2548

Publication date Collection: December 2021

Publication date (Electronic, pub): 17 December 2021

Volume: 7

Issue: 51

Electronic Location Identifier: eabl5862

Affiliations

[1 ]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.

[2 ]The Fourth Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.

[3 ]Amoy Hopeful Biotechnology Co. Ltd., Xiamen 361027, China.

[4 ]Departments of Diagnostic Radiology, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, Singapore.

[5 ]Department of Radiology, Xiang’an Hospital of Xiamen University, Xiamen 361102, China.

[6 ]The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.

Author notes

[* ]Corresponding author. Email: gangliu.cmitm@ 123456xmu.edu.cn (G.L.); fwang@ 123456zju.edu.cn (F.W.); maojingsong163@ 123456163.com (J.M.).

Author information

Huirong Lin https://orcid.org/0000-0002-0798-8280

Jiaming Wang https://orcid.org/0000-0001-7881-7158

Tianhong Yao https://orcid.org/0000-0003-1615-0946

Hu Chen https://orcid.org/0000-0003-4860-6223

Yang Zhang https://orcid.org/0000-0002-3476-8937

En Ren https://orcid.org/0000-0002-4976-5050

Chengchao Chu https://orcid.org/0000-0002-1694-9363

Xiaoyuan Chen https://orcid.org/0000-0002-9622-0870

Jingsong Mao https://orcid.org/0000-0002-9973-5263

Fudi Wang https://orcid.org/0000-0001-8730-0003

Gang Liu https://orcid.org/0000-0003-2613-7286

Article

Publisher ID: abl5862

DOI: 10.1126/sciadv.abl5862

PMC ID: 8682994

PubMed ID: 34919434

SO-VID: 4397fb63-a395-4986-a55f-2daa3d7eaa97

Copyright © Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.