Raw Milk Consumption and Other Early-life Farm Exposures and Adult Pulmonary Function
      in the Agricultural Lung Health Study

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Abstract

Literature suggests that early exposure to the farming environment protects against atopy and asthma; few studies have examined pulmonary function. We evaluated associations between early-life farming exposures and pulmonary function in 3,061 adults (mean age=63) from a US farming population using linear regression. Childhood raw milk consumption was associated with higher forced expiratory volume in the first second (FEV ₁) (β=49.5ml; 95%CI=2.8,96.1ml; p=0.04) and forced vital capacity (FVC) (β=66.2ml, 95%CI=13.2–119.1ml, p=0.01). We did not find appreciable associations with other early-life farming exposures. We report a novel association between raw milk consumption and higher pulmonary function that lasts into older adulthood.

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Journal

Journal ID (nlm-journal-id): 0417353

Journal ID (pubmed-jr-id): 7730

Journal ID (nlm-ta): Thorax

Journal ID (iso-abbrev): Thorax

Title: Thorax

ISSN (Print): 0040-6376

ISSN (Electronic): 1468-3296

Publication date Nihms-submitted: 18 August 2017

Publication date (Electronic): 08 July 2017

Publication date (Print): March 2018

Publication date PMC-release: 01 March 2019

Volume: 73

Issue: 3

Pages: 279-282

Affiliations

[1 ]Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC

[2 ]Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC

[3 ]Bioinformatics Research Center, North Carolina State University, Raleigh, NC

[4 ]Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC

[5 ]Westat, Durham, NC

[6 ]Hankinson Consulting, Inc., Valdosta, GA

[7 ]Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV

[8 ]Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD

[9 ]Social & Scientific Systems, Inc., Durham, NC

[10 ]Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC

Author notes

Corresponding Author: Stephanie London, MD, DrPH, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, Research Triangle Park, NC, 27709, london2@ 123456niehs.nih.gov , fax: 301-480-3290

Article

Accession ID: PMC5758444 Pmcid ID: PMC5758444 Pmc-uid ID: 5758444 Manuscript ID: nihpa897346

DOI: 10.1136/thoraxjnl-2017-210031

PMC ID: 5758444

PubMed ID: 28689172

SO-VID: 43d2d52c-e4d3-466a-9c56-a844c9b89924

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Raw Milk Consumption and Other Early-life Farm Exposures and Adult Pulmonary Function in the Agricultural Lung Health Study

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