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      Renin Release and the Refractoriness to Acute Renal Failure of Rats Recovering from Prior Renal Failure

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          Abstract

          Renin substrate concentrations and the release of renin in response to the rapid removal of 15 ml/kg body weight blood or subcutaneous administration of 500 µg/kg body weight isoproterenol were measured in control rats and animals recovering from prior myohemoglobinuric acute renal failure (recovery rats). Blood for these assayas was drawn from chronically implanted aortic catheters, obviating the need for animal handling and anesthesia. Baseline plasma renin titers of recovery rats were modestly elevated but renin substrate concentrations were the same as in controls. Hemorrhage produced equivalent changes in blood pressure and plasma renin titer in the two groups. Isoproterenol injection in recovery rats caused a somewhat greater blood pressure fall and almost twice the rise in plasma renin concentration observed in control rats. The marked resistance of recovery animals to a second bout of acute renal failure thus cannot be attributed to impaired renin release or inadequate plasma renin substrate.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2981-5
          978-3-318-02025-0
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 1-3
          : 107-112
          Affiliations
          Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Mass., and the Medical College of Virginia, and McGuire Veteran’s Hospital, Richmond, Va.
          Article
          181429 Nephron 1978;22:107–112
          10.1159/000181429
          745630
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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