103
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.

      Nature

      Antiviral Agents, therapeutic use, CD4 Lymphocyte Count, drug effects, CD4-Positive T-Lymphocytes, cytology, virology, HIV Infections, drug therapy, immunology, HIV Protease Inhibitors, HIV-1, physiology, Humans, Kinetics, Ritonavir, Viremia, Virion, Virus Replication

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

          Related collections

          Author and article information

          Journal
          7816094
          10.1038/373123a0

          Comments

          Comment on this article