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      Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond

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          The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine

          Images Figs. 15-18 Figs. 7-10 Figs. 11-14 Figs. 1-6
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            Biological nitric oxide signalling: chemistry and terminology.

            Biological nitrogen oxide signalling and stress is an area of extreme clinical, pharmacological, toxicological, biochemical and chemical research interest. The utility of nitric oxide and derived species as signalling agents is due to their novel and vast chemical interactions with a variety of biological targets. Herein, the chemistry associated with the interaction of the biologically relevant nitrogen oxide species with fundamental biochemical targets is discussed. Specifically, the chemical interactions of nitrogen oxides with nucleophiles (e.g. thiols), metals (e.g. hemeproteins) and paramagnetic species (e.g. dioxygen and superoxide) are addressed. Importantly, the terms associated with the mechanisms by which NO (and derived species) react with their respective biological targets have been defined by numerous past chemical studies. Thus, in order to assist researchers in referring to chemical processes associated with nitrogen oxide biology, the vernacular associated with these chemical interactions is addressed. © 2013 The British Pharmacological Society.
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              Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence

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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Organic Process Research & Development
                Org. Process Res. Dev.
                American Chemical Society (ACS)
                1083-6160
                1520-586X
                September 18 2020
                July 28 2020
                September 18 2020
                : 24
                : 9
                : 1558-1585
                Affiliations
                [1 ]Lhasa Limited, Leeds, West Yorkshire LS11 5PS, U.K.
                Article
                10.1021/acs.oprd.0c00323
                45f0cb93-4ed9-4966-8bd2-c922efb3b8b9
                © 2020

                https://doi.org/10.15223/policy-029

                https://doi.org/10.15223/policy-037

                https://doi.org/10.15223/policy-045

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