Oxymatrine Ameliorates Doxorubicin-Induced Cardiotoxicity in Rats.

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Abstract

Doxorubicin-induced cardiac toxicity has been a major concern of oncologists and is considered the main restriction on its clinical application. Oxymatrine has shown potent anti-cancer, anti-fibrosis, and anti-oxidative effects. Recently, it has been reported that oxymatrine is protective against some cardiovascular diseases. In this study, we aimed to investigate the effects of oxymatrine on doxorubicin-induced cardiotoxicity in rat hearts and H9c2 cells.

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Journal

Journal ID (iso-abbrev): Cell. Physiol. Biochem.

Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Publisher: S. Karger AG

ISSN (Electronic): 1421-9778

ISSN (Print): 1015-8987

Publication date (Electronic): 2017

Volume: 43

Issue: 2

Affiliations

[1 ] Department of Pharmacology, Guizhou Medical University, Guizhou, China.

[2 ] Information Security and Big Data Research Institute & School of Life Sciences, Central South University, Changsha, China.

[3 ] Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA.

Article

Publisher Item ID: 000480471

DOI: 10.1159/000480471

PubMed ID: 28946137

SO-VID: 4655f2c2-52d5-476f-9cc7-3f061249c885

History

Keywords: Doxorubicin,Oxidative stress,Oxymatrine,Apoptosis,Cardiotoxicity

Data availability:

Keywords: Doxorubicin, Oxidative stress, Oxymatrine, Apoptosis, Cardiotoxicity

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