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      The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats

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          Abstract

          PURPOSE: To evaluate macro and microscopically, changes following the use of the aqueous extract of babassu (Orbignya phalerata) in the lung parenchyma and pleura of rats. METHODS: Sixty adult male rats with average weight of 350 g, were randomized into two groups of 30 animals (experimental and control) further divided into sub-groups of 10 to be sacrificed at 48 h, 72 h and 21 days. The substance was injected into the right pleura of the animals. RESULTS: There was intense pleuropulmonary macroscopic reaction with statistically significant differences between groups respectively (p<0.05, p<0.02, p<0.03). Microscopically, no statistically significant difference was evident (p>0.05). CONCLUSION: The aqueous extract of babassu (Orbignya phalerata) was found to be highly irritating to the pleura and lung of rats, evidenced macroscopically by numerous adhesions and inflammation while no major changes were evident microscopically.

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          Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review

          Robert Klopfleisch (2013)
          Background Histopathology has initially been and is still used to diagnose infectious, degenerative or neoplastic diseases in humans or animals. In addition to qualitative diagnoses semiquantitative scoring of a lesion`s magnitude on an ordinal scale is a commonly demanded task for histopathologists. Multiparametric, semiquantitative scoring systems for mouse models histopathology are a common approach to handle these questions and to include histopathologic information in biomedical research. Results Inclusion criteria for scoring systems were a first description of a multiparametric, semiquantiative scoring systems which comprehensibly describe an approach to evaluate morphologic lesion. A comprehensive literature search using these criteria identified 153 originally designed semiquantitative scoring systems for the analysis of morphologic changes in mouse models covering almost all organs systems and a wide variety of disease models. Of these, colitis, experimental autoimmune encephalitis, lupus nephritis and collagen induced osteoarthritis colitis were the disease models with the largest number of different scoring systems. Closer analysis of the identified scoring systems revealed a lack of a rationale for the selection of the scoring parameters or a correlation between scoring parameter value and the magnitude of the clinical symptoms in most studies. Conclusion Although a decision for a particular scoring system is clearly dependent on the respective scientific question this review gives an overview on currently available systems and may therefore allow for a better choice for the respective project.
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            An anti-inflammatory and immunomodulatory polysaccharide from Orbignya phalerata.

            Bernadete Pereira da Silva, José Paz Parente (2001)
            A polysaccharide, a glucan with mean M(r) of 1.0 x 10(6) (MP1), was isolated from the mesocarp of fruits of Orbignya phalerata. Chemical and spectroscopic studies indicated that MP1 has a highly branched glucan type structure composed of alpha-(1-->4) linked D-glucopyranose residues with (3-->4), (4-->6), and with (3-->6) branching points. MP1 enhanced phagocytosis in vivo and exhibited anti-inflammatory activity.
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              Pleural FDG Uptake More Than a Decade after Talc Pleurodesis

              Hilke Peek, Wouter van der Bruggen, Gijs Limonard (2009)
              Talc pleurodesis induces a strong local inflammatory reaction which can be detected by PET scan for years after the procedure. When patients undergo PET scanning in the workup of a suspected malignancy later in life, pleural FDG uptake may unnecessarily lead to an additional invasive diagnostic workup. We present two cases of positive pleural PET findings more than 10 years after talc pleurodesis, where we adopted a watchful waiting approach. Positive pleural PET findings as a result of prior talc pleurodesis should always be included in the differential diagnosis of pleural abnormalities.
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                Author and article information

                Contributors
                Elias Amorim: Role: ND
                Roberto Saad Junior: Role: ND
                Natalino Salgado Filho: Role: ND
                George Castro Figueira de Melo: Role: ND
                Gyl Eanes Barros Silva: Role: ND
                Rennan Abud Pinheiro Santos: Role: ND
                Danilo Dallago de Marchi: Role: ND
                Ricardo Comunello de Carli: Role: ND
                Osvaldo Malafaia: Role: ND
                Jurandir Ribas-Filho: Role: ND
                Journal
                Journal ID (publisher): acb
                Title: Acta Cirurgica Brasileira
                Abbreviated Title: Acta Cir. Bras.
                Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
                ISSN: 1678-2674
                Publication date (Print): April 2016
                Volume: 31
                Issue: 4
                Pages: 243-249
                Affiliations
                [1 ] Universidade Federal do Maranhão Brazil
                [2 ] Santa Casa de São Paulo Brazil
                [3 ] Universidade Federal do Maranhão Brazil
                [4 ] Universidade Federal do Maranhão Brazil
                [5 ] Universidade Federal do Maranhão Brazil
                [6 ] Universidade Federal do Maranhão Brazil
                [7 ] Faculdade Evangélica do Paraná Brazil
                [8 ] FEPAR Brazil
                Article
                Publisher ID: S0102-86502016000400243
                DOI: 10.1590/S0102-865020160040000004
                SO-VID: 479f041d-9bfb-436c-baf0-8b9e4680c999
                License:

                This work is licensed under a Creative Commons Attribution 4.0 International License.

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                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0102-8650&lng=en
                Categories
                Subject: SURGERY

                ScienceOpen disciplines: Surgery
                Keywords: Plants, Medicinal,Phytotherapy,Pleura,Lung,Rats
                Data availability:
                ScienceOpen disciplines: Surgery
                Keywords: Plants, Medicinal, Phytotherapy, Pleura, Lung, Rats

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