Blog
About

13
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells.

      The EMBO Journal

      Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, drug effects, cytology, Stem Cells, Mice, Transgenic, Mice, Inbred C57BL, Mice, Male, pharmacology, Lymphokines, Leukocytes, Mononuclear, Humans, Flow Cytometry, Endothelium, Vascular, Endothelial Growth Factors, biosynthesis, DNA, Corneal Neovascularization, Corneal Injuries, Cornea, Chemotaxis, Cells, Cultured, Cell Movement, Cell Count, Bone Marrow Transplantation, Bone Marrow Cells, Animals

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Vascular endothelial growth factor (VEGF) has been shown to promote neovascularization in animal models and, more recently, in human subjects. This feature has been assumed to result exclusively from its direct effects on fully differentiated endothelial cells, i.e. angiogenesis. Given its regulatory role in both angiogenesis and vasculogenesis during fetal development, we investigated the hypothesis that VEGF may modulate endothelial progenitor cell (EPC) kinetics for postnatal neovascularization. Indeed, we observed an increase in circulating EPCs following VEGF administration in vivo. VEGF-induced mobilization of bone marrow-derived EPCs resulted in increased differentiated EPCs in vitro and augmented corneal neovascularization in vivo. These findings thus establish a novel role for VEGF in postnatal neovascularization which complements its known impact on angiogenesis.

          Related collections

          Author and article information

          Journal
          10.1093/emboj/18.14.3964
          10406801
          1171472

          Comments

          Comment on this article