Analysis on consistently positive of SARS-CoV-2 nucleic acid test into multiple samples from a patient with COVID-19

Abstract

At present, Coronavirus Disease 2019 (COVID-19) is spreading rapidly in China and other countries. The clinical symptoms of patients infected with SARS-CoV-2 are different, or even appear to be asymptomatic, which put forward higher requirements for the prevention and control of the entire epidemic. The SARS-CoV-2 nucleic acid test was used as the mean method for diagnosis of COVID-19. The present study reports a case of COVID-19 with no obvious gastrointestinal symptoms, but with consistently positive nucleic acid test into fecal and anal swab samples. The patient study in a university in Wuhan,he had respiratory symptoms during his school, and then returned home on winter vacation. The patient was admitted to the hospital because his condition was aggravated. According to the development of the disease and the needs of diagnosis and treatment, the patient underwent multiple nucleic acid tests for SARS-COV-2. As the symptoms improved significantly, the nucleic acid test of the sputum, anal swab and feces samples continued to be positive after the conversion of pharyngeal samples. So we uncover the clinical significance of nucleic acid test of SARS-CoV-2 from more than one specimen for diagnosing or treatment of COVID-19, and explore the epidemic prevention and control strategy of COVID-19.

Abstract

摘要： 目前新型冠状病毒肺炎 (COVID-19) 正在我国及世界其他国家流行, 患者感染病毒后的临床症状不一, 甚至呈现为无症状感染状态, 这给整个疫情的防控提出了更高的要求。新型冠状病毒 (SARS-CoV-2) 核酸检测作为COV-ID-19诊断的主要手段, 在抗击疫情的过程中发挥着重要的作用, 因此备受关注。本文报告一例无明显消化道症状, 但粪便及肛拭子核酸检查持续阳性的COVID-19病例。患者为武汉某大学在校学生, 在校期间即出现呼吸道症状, 后放假回家, 因病情加重而就诊入院, 根据病情发展和诊疗需要, 该患者进行了多次核酸检测, 在症状明显好转, 咽拭子核酸检测转阴后, 其痰液、肛拭子及粪便样本的核酸检测仍持续阳性, 由此, 讨论多部位样本核酸检测对COVID-19诊疗的临床意义, 并探讨疫情防控策略。