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      • Record: found
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      Is Open Access

      Impulse control disorders in Parkinson disease and RBD : A longitudinal study of severity

      research-article
      Author(s): , MRCP, PhD, , MBBch, BAO, , MPhil, , MRCP, PhD, , MRCP, DPhil, , MD, PhD, , MRCP, , MRCP, , PhD, , MD(Res), MRCPsych, , PhD, FRCP
      Publication date PMC-release:
      Journal: Neurology
      Publisher: Lippincott Williams & Wilkins

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          Abstract

          Objective

          To describe the prevalence, natural history, and risk factors for impulse control behaviors (ICBs) among people with Parkinson disease (PD), those with REM sleep behavior disorder (RBD), and controls.

          Methods

          Participants with early PD (within 3.5 years of diagnosis), those with RBD, and controls were clinically phenotyped and screened for ICBs longitudinally (with the Questionnaire for Impulsivity in Parkinson's Disease). ICB-positive individuals were invited for a semistructured interview, repeated 1 year later. The severity of the ICB was assessed with the Parkinson's Impulse Control Scale. Multiple imputation and regression models were used to estimate ICB prevalence and associations.

          Results

          Data from 921 cases of PD at baseline, 768 cases at 18 months, and 531 cases at 36 months were included, with 21% to 25% screening positive for ICBs at each visit. Interviews of ICB screen–positive individuals revealed that 10% met formal criteria for impulse control disorders (ICD), while 33% had subsyndromal ICD (ICB symptoms without reaching the formal diagnostic criteria for ICD). When these data were combined through the use of multiple imputation, the prevalence of PD-ICB was estimated at 19.1% (95% confidence interval 10.1–28.2). On follow-up, 24% of cases of subsyndromal ICD had developed full symptoms of an ICD. PD-ICD was associated with dopamine agonist use, motor complications, and apathy but not PD-RBD. ICD prevalence in the RBD group (1%) was similar to that in controls (0.7%).

          Conclusions

          ICBs occur in 19.1% of patients with early PD, many persisting or worsening over time. RBD is not associated with increased ICD risk. Psychosocial drivers, including mood and support networks, affect severity.

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          Most cited references31

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          Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

          A J Hughes, S Daniel, L Kilford … (1992)
          Few detailed clinico-pathological correlations of Parkinson's disease have been published. The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported. Seventy six had nigral Lewy bodies, and in all of these Lewy bodies were also found in the cerebral cortex. In 24 cases without Lewy bodies, diagnoses included progressive supranuclear palsy, multiple system atrophy, Alzheimer's disease, Alzheimer-type pathology, and basal ganglia vascular disease. The retrospective application of recommended diagnostic criteria improved the diagnostic accuracy to 82%. These observations call into question current concepts of Parkinson's disease as a single distinct morbid entity.
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            Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease.

            Daniel Weintraub, Staci Hoops, Judy A. Shea … (2009)
            As no comprehensive assessment instrument for impulse control disorders (ICDs) in Parkinson's disease (PD) exists, the aim of this study was to design and assess the psychometric properties of a self-administered screening questionnaire for ICDs and other compulsive behaviors in PD. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP) has 3 sections: Section 1 assesses four ICDs (involving gambling, sexual, buying, and eating behaviors), Section 2 other compulsive behaviors (punding, hobbyism, and walkabout), and Section 3 compulsive medication use. For validation, a convenience sample of 157 PD patients at 4 movement disorders centers first completed the QUIP, and then was administered a diagnostic interview by a trained rater blinded to the QUIP results. A shortened instrument (QUIP-S) was then explored. The discriminant validity of the QUIP was high for each disorder or behavior (receiver operating characteristic area under the curve [ROC AUC]: gambling = 0.95, sexual behavior = 0.97, buying = 0.87, eating = 0.88, punding = 0.78, hobbyism = 0.93, walkabout = 0.79). On post hoc analysis, the QUIP-S ICD section had similar properties (ROC AUC: gambling = 0.95, sexual behavior = 0.96, buying = 0.87, eating = 0.88). When disorders/behaviors were combined, the sensitivity of the QUIP and QUIP-S to detect an individual with any disorder was 96 and 94%, respectively. Scores on the QUIP appear to be valid as a self-assessment screening instrument for a range of ICDs and other compulsive behaviors that occur in PD, and a shortened version may perform as well as the full version. A positive screen should be followed by a comprehensive, clinical interview to determine the range and severity of symptoms, as well as need for clinical management. Copyright 2009 Movement Disorder Society.
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              Association of dopamine agonist use with impulse control disorders in Parkinson disease.

              Daniel Weintraub, Joseph S. Goveas, Daniel Stern … (2006)
              To determine the frequency and correlates of impulse control disorders (ICDs) in Parkinson disease (PD). An unstructured screening interview for ICDs (compulsive gambling, buying, and sexual behavior) followed by a telephone-administered structured interview for screen-positive patients. Two university-affiliated movement disorders centers. A convenience sample of 272 patients with idiopathic PD who were screened for psychiatric complications. Presence of compulsive gambling, buying, or sexual behavior as assessed by the Minnesota Impulsive Disorders Interview. Eighteen patients (6.6%) with PD met criteria for an ICD at some point during the course of PD, including 11 (4.0%) with an active ICD. Compulsive gambling and compulsive sexual behavior were equally common. In a multivariate model, treatment with a dopamine agonist (P = .01) and a history of ICD symptoms prior to PD onset (P = .02) predicted current ICD. There were no differences between the dopamine agonists in their association with ICDs (P = .21), and daily doses of dopamine agonists were higher in patients with an ICD than in dopamine agonist-treated patients without an ICD (P < .001). Patients with PD treated with a dopamine agonist should be made aware of the risk of developing an ICD and monitored clinically. Because dopamine agonists are increasingly being used for other indications, future research should assess the dopamine agonist-associated risk for ICDs in other populations.
              Article 0 comments Cited 124 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Fahd Baig:
                ORCID: http://orcid.org/0000-0002-3315-2698
                Comment :

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                Mark J. Kelly:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1) Parkinson Voice Project, Dallas, Texas, travel bursary and honorarium for an invited lecture.

                Editorial Boards:

                1. NONE

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                1. NONE

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                1. NONE

                Employment, Commercial Entity:

                1. (1) Oxford University Hospitals NHS Foundation Trust, core medical trainee, 2018-2019. (2) Nuffield Department of Clinical Neurosciences, honorary research fellow, 2017-2019.

                Consultancies:

                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                Michael A. Lawton:
                Comment :

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                1. NONE

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                Funding for travel or speaker honoraria:

                1. (1) European Charcot Foundation, travel expenses to attend 26th Annual meeting

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                1. NONE

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                1. NONE

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                1. NONE

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                1. (1) Parkinson's UK fund the study I work on and in effect pay my salary Stock/Stock Options, Medical Equipment & Materials: (1) Risk Based Approach Ltd., 2017-2019

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

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                Claudio Ruffmann:
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                1. NONE

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                1. Hampshire Hospitals NHS Foundation Trust, 2016 - University of Oxford, Clinical Research fellow, 2013 - 2016

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                1. NONE

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                1. NONE

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                1. NONE

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                Michal Rolinski:
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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

                Research Support, Government Entities:

                1. (1) NIHR, Academic Clinical Lecturer, 2017-2021

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. (1) Academy of Medical Sciences (2) Wellcome Trust (3) David Telling Trust

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                Johannes C. Klein:
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                1. Dr Klein has received royalties for the book Diseases of the Spinal Cord: Novel Imaging, Diagnosis and Treatment, Springer 2015.

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                1. J.C.K. has received salary from the National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre.

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                Thomas Barber:
                Comment :

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

                Research Support, Foundations and Societies:

                1. The Wellcome Trust

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                1. NONE

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                Christine Lo:
                Comment :

                Scientific Advisory Boards:

                1. NONE

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. Movement Disorders Society Travel grant to attend the Movement Disorders Society Congress in Hong Kong in October 2018

                Editorial Boards:

                1. NONE

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                1. NONE

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                1. NONE

                Employment, Commercial Entity:

                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. Funding from the NIHR Oxford Biomedical research centre - salary. Employed as clinical research fellow from July 2017 to present.

                Research Support, Academic Entities:

                1. NONE

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                1. NONE

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                Yoav Ben-Shlomo:
                Comment :

                Scientific Advisory Boards:

                1. 1. Chair of TSC for the REACT trial (non-profit entity) 2. Member of TSC for the AIM HY INFORM study (non-profit entity) 3. Member of TSC for the SIMPLIFIED RCT(non-profit entity)

                Gifts:

                1. NONE

                Funding for travel or speaker honoraria:

                1. (1) Recieve payment for a teaching session on the Birmingham Movement Disorders course on the epidemiology of PD (non-profit entity)

                Editorial Boards:

                1. NONE

                Patents:

                1. NONE

                Publishing Royalties:

                1. Co-edit a book called "A life course approach to chronic disease epidemiology" published by OUP. 2nd edition 2004 and co-editor of Epidemiology, Evidence-Based Medicine and Public Health (Wiley-Blackwell)

                Employment, Commercial Entity:

                1. NONE

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                1. NONE

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                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. (1) Hong Kong General Research Fund (GRF) Early Career Scheme (ECS) Employment Conditions and Health among Female Foreign Domestic Workers in Hong Kong. A Cross- sectional Quantitative Survey. Research Grants Council (RGC) 24614518; 01/01/2019 ? 31/12/2020; $889,984 (HKD). PI: Roger Yat-Nork Chung, Co-I: Yoav Ben-Shlomo; Sabu Padmadas; Eric Fong; Tim Liao; Petula Sik Ying Ho (2) NIHR Health Technology Assessment Programme Henderson E, Ben-Shlomo Y, Hollingworth W, Metcalfe C, Steeds D, Whone A. A phase III trial of Rivastigmine to prevent falls in Parkinson's Disease: CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson?s Disease). Total award ?2,545,636.88 Duration 51 months starting 01/01/2019 (3) MRC Dementia Momentum award Ben-Shlomo Y, Coulthard EJ, Craddock I, Newson M, Santos- Rodriguez R. ContinUous behavioUral Biomarkers Of cognitive Impairment (CUBOId) ?817,000 over 36 months (01/04/2017-01/04/2020). (4) NIHR Health Technology Assessment Programme Caskey F, Chilcot J, Ben-Shlomo Y, Salisbury C, Abbott D, Coast J, Donovan J, Burns A, Murphy E, Murtagh F, Huxtable R, Davies SJ, Rayner H, Farrington K, Rooshenas L, Roderick P, MacNeil S, Gibson A, Lane A. The Prepare Multi-Morbid Older People for End-stage Kidney Disease Trial (PrepareME) ?2,818,119.12 01/01/2017 to 31/12/2021 (60 months) (5) NIHR Health Technology Assessment Programme Caskey F, MacNeil S, May M, Lane A, Hollingworth W, Ben- Shlomo Y, Donovan J, Rooshenas L, Abbott D, Farrington K, Davenport A, Wheeler D, Power A, Mitra S. The High-volume Haemodiafiltration vs High-flux Haemodialysis Registry Trial (H4RT) ?1,738,553.78 01/01/2017 to 31/12/2021 (6) NIHR Health Technology Assessment Programme Rai D, Ben-Shlomo Y, Davies N, Evans J, Gunnell D, Jackson R, Martin R, Morris R. Antidepressant use during pregnancy: assessing benefits to mothers and long-term neurodevelopmental risks to children using the Clinical Practice Research Datalink. ?301,424 Nov 2016 ? Nov 2018.

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. (1) Parkinson?s UK Tracking Parkinson?s: The long term development and analysis of the Parkinson?s repository of biomarkers and networked datasets Award amount ?1,517,866.25 (48 months) Applicants: Grossett D, Bajaj N, Barker RA, Ben-Shlomo Y, Burn D, Foltynie T, Morris H, Williams N, Wood N. Start date Nov 2016-Nov 2020 (2) The Alberta Centre for Child Family and Community Research Relationship between lifestyle behaviours, social determinants of health, and mental health in Canadian immigrants across the life span. $40,000 over 12 months (01/03/2016 to 01/03/2017) Applicants Bukola Salami (PI); Kathleen Hegadoren (Co- PI); Leonelo Bautista; Esperanza Diaz; Anu Rammohan; Yoav Ben-Shlomo; Salima Meherali; Yvonne Chiu; Christina Nsaliwa; (3) Kidney Research UK Bailey P, Caskey F, Ben-Shlomo Y, MacNeill S. What factors explain the association between socioeconomic deprivation and a reduced likelihood of live-donor kidney transplantation? A questionnaire based case-control study (2017; ?43,855 over 1 year) (4) Gatsby Foundation: Henderson E, Ben-Shlomo Y, Hollingworth W, Metcalfe C, McCarthy E. Proactive and Integrated Management and Empowerment in Parkinson?s Disease (PRIME-PD). ?3,220,000 (?2,869,000) Duration eight years starting 1st Jan 2019

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                David Okai:
                Comment :

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

                Consultancies:

                1. NONE

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                1. NONE

                Other Activities:

                1. NONE

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                1. NONE

                Research Support, Commercial Entities:

                1. NONE

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                1. NONE

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. NONE

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                1. NONE

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                Michele T. Hu:
                Comment :

                Scientific Advisory Boards:

                1. (1) Commercial or non-profit entity: Roche Prodromal Advisory Board, Biogen Digitals Advisory Board

                Gifts:

                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

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                1. NONE

                Employment, Commercial Entity:

                1. NONE

                Consultancies:

                1. NONE

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                1. NONE

                Other Activities:

                1. NONE

                Clinical Procedures or Imaging Studies:

                1. NONE

                Research Support, Commercial Entities:

                1. NONE

                Research Support, Government Entities:

                1. (1) National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals NHS Trust and University of Oxford, Project grant: Neurological conditions sub-theme, Clinical Fellowship Salary and consumables support, 2018 - ongoing

                Research Support, Academic Entities:

                1. NONE

                Research Support, Foundations and Societies:

                1. (1) Parkinson's UK Monument Trust Discovery Award, 2010-2018, Grant Number J-1403 (2) Michael J Fox Foundation

                Stock/Stock Options/Board of Directors Compensation:

                1. NONE

                License Fee Payments, Technology or Inventions:

                1. NONE

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                Journal
                Journal ID (nlm-ta): Neurology
                Journal ID (iso-abbrev): Neurology
                Journal ID (hwp): neurology
                Journal ID (publisher-id): neur
                Journal ID (pmc): neurology
                Journal ID (publisher-id): NEUROLOGY
                Title: Neurology
                Publisher: Lippincott Williams & Wilkins (Hagerstown, MD )
                ISSN (Print): 0028-3878
                ISSN (Electronic): 1526-632X
                Publication date (Print): 13 August 2019
                Publication date PMC-release: 13 August 2019
                Volume: 93
                Issue: 7
                Pages: e675-e687
                Affiliations
                From the Oxford Parkinson's Disease Centre (F.B., M.J.K., M.A.L., C.R., M.R., J.C.K., T.B., C.L., Y.B.-S., D.O., M.T.H.), and Nuffield Department of Clinical Neurosciences (F.B., M.J.K.), University of Oxford; Population Health Sciences (M.A.L., Y.B.-S.) and Translational Health Sciences (M.R.), University of Bristol; and Department of Psychological Medicine (D.O.), Oxford University Hospitals NHS Trust, UK.
                Author notes
                Correspondence Dr. Hu Michele.hu@ 123456ndcn.ox.ac.uk

                Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

                [*]

                These authors contributed equally to this work.

                The Article Processing Charge was funded by Parkinson's UK.

                Author information
                http://orcid.org/0000-0002-3315-2698
                Article
                Publisher ID: NEUROLOGY2018963314 Accession ID: 00010
                DOI: 10.1212/WNL.0000000000007942
                PMC ID: 6715510
                PubMed ID: 31311842
                SO-VID: 4a8a371a-ea1e-46fe-a765-81683174d316
                Copyright © Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 24 December 2018
                Date accepted : 28 March 2019
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                Subject: 165
                Subject: Article
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