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      Absence of Mycoplasma Contamination in the Anthrax Vaccine

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Mycoplasma contamination of the licensed anthrax vaccine administered to military personnel has been suggested as a possible cause of Persian Gulf illness. Vaccine samples tested by nonmilitary laboratories were negative for viable mycoplasma and mycoplasma DNA and did not support its survival. Mycoplasma contamination of anthrax vaccine should not be considered a possible cause of illness.

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          Most cited references5

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          The Vaccine Adverse Event Reporting System (VAERS).

          (1994)
          Immunizations against most vaccine-preventable diseases will be needed indefinitely unless the disease is eradicated. Public acceptance of immunizations may be threatened as vaccine coverage increases and disease decreases, however, due to the increase in both causally and coincidentally related vaccine adverse events. The post-marketing surveillance for such events in the USA in response to the mandatory reporting requirements of the National Childhood Injury Act of 1986. While VAERS has many methodological limitations intrinsic to such systems, it can play an important role in helping to monitor vaccine safety and maintain public confidence in immunizations.
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            Genetic and serologic relatedness between Mycoplasma fermentans strains and a mycoplasma recently identified in tissues of AIDS and non-AIDS patients.

            C Saillard, P Carle, J Bové … (2015)
            A mycoplasma previously identified in the tissues of both AIDS and non-AIDS patients dying of an acute fatal disease was earlier shown to share some biologic and genetic properties with a strain of Mycoplasma fermentans, an organism occurring infrequently in the human lower urogenital tract. More extensive genetic and serologic comparisons using DNA/DNA hybridization, DNA base composition (guanine + cytosine), restriction endonuclease DNA analysis, cellular protein patterns and metabolism inhibition serologic procedures confirm that the organism previously designated as "Mycoplasma incognitus" (Mi) is indeed very closely related to strains of M. fermentans. While the genetic and serologic features observed among the newly isolated mycoplasma and two M. fermentans strains suggest a species relationship, it now seems useful to re-examine the biological activities of other freshly isolated M. fermentans strains from man.
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              M-CMRL, a new axenic medium to replace indicator cell cultures for the isolation of all strains of Mycoplasma hyorhinis.

              R Giudice (1998)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): January 2002
                Volume: 8
                Issue: 1
                Pages: 94-96
                Affiliations
                [* ]United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
                [† ]National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland, USA
                Author notes
                Address for correspondence: George Korch, USAMRIID, 1425 Porter Street, Frederick, MD 21702, USA; fax: 301-619-4625; e-mail: george.korch@ 123456det.amedd.army.mil
                Article
                Publisher ID: 01-0091
                DOI: 10.3201/eid0801.010091
                PMC ID: 2730269
                PubMed ID: 11840996
                SO-VID: 4babecbe-339c-4b6b-818c-04fbb06c55cc
                History
                Categories
                Subject: Dispatch

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: anthrax,mycoplasma,vaccine
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: anthrax, mycoplasma, vaccine

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