For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
4
views
201
references
 Top references
cited by
11
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      463
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Immuno-Metabolism: The Role of Cancer Niche in Immune Checkpoint Inhibitor Resistance

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The use of immune checkpoint inhibitors (ICI) in treating cancer has revolutionized the approach to eradicate cancer cells by reactivating immune responses. However, only a subset of patients benefits from this treatment; the majority remains unresponsive or develops resistance to ICI therapy. Increasing evidence suggests that metabolic machinery in the tumor microenvironment (TME) plays a role in the development of ICI resistance. Within the TME, nutrients and oxygen are scarce, forcing immune cells to undergo metabolic reprogramming to adapt to harsh conditions. Cancer-induced metabolic deregulation in immune cells can attenuate their anti-cancer properties, but can also increase their immunosuppressive properties. Therefore, targeting metabolic pathways of immune cells in the TME may strengthen the efficacy of ICIs and prevent ICI resistance. In this review, we discuss the interactions of immune cells and metabolic alterations in the TME. We also discuss current therapies targeting cellular metabolism in combination with ICIs for the treatment of cancer, and provide possible mechanisms behind the cellular metabolic rewiring that may improve clinical outcomes.

          Related collections

          Most cited references201

          • Record: found
          • Abstract: found
          • Article: not found

          Inflammation and cancer.

          Lisa Coussens, Zena Werb (2002)
          Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.
          Article 0 comments Cited 1811 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The biology and function of fibroblasts in cancer.

            Raghu Kalluri (2016)
            Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal to all other cells, and they are the only normal cell type that can be live-cultured from post-mortem and decaying tissue. Their resilient adaptation may reside in their intrinsic survival programmes and cellular plasticity. Cancer is associated with fibroblasts at all stages of disease progression, including metastasis, and they are a considerable component of the general host response to tissue damage caused by cancer cells. Cancer-associated fibroblasts (CAFs) become synthetic machines that produce many different tumour components. CAFs have a role in creating extracellular matrix (ECM) structure and metabolic and immune reprogramming of the tumour microenvironment with an impact on adaptive resistance to chemotherapy. The pleiotropic actions of CAFs on tumour cells are probably reflective of them being a heterogeneous and plastic population with context-dependent influence on cancer.
            Article 0 comments Cited 1198 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Inflammation and Cancer: Triggers, Mechanisms, and Consequences

              Florian Greten, Sergei I. Grivennikov (2019)
              Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are highly plastic, continuously changing their phenotypic and functional characteristics. Here we review the origins of inflammation in tumors, and the mechanisms whereby inflammation drives tumor initiation, growth, progression and metastasis. We discuss how tumor promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis or tissue repair, and illuminate the distinctions between tissue-protective and pro-tumorigenic inflammation, including spatio-temporal considerations. Defining the cornerstone rules of engagement governing molecular and cellular mechanisms of tumor-promoting inflammation will be essential for the further development of anti-cancer therapies. Grivennikov and Greten review the mechanisms underlying the initiation of pro-tumorigenic inflammatory responses, how these evolve throughout the different stages of tumor development and the plasticity of the cells within the tumor microenvironment.
              Article 0 comments Cited 1112 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Laura Strauss: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 27 January 2021
                Publication date Collection: February 2021
                Volume: 22
                Issue: 3
                Electronic Location Identifier: 1258
                Affiliations
                [1 ]School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan; b313107058@ 123456tmu.edu.tw
                [2 ]Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; m120107009@ 123456tmu.edu.tw
                [3 ]Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
                [4 ]School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33382, Taiwan
                [5 ]Division of Internal Medicine, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan
                [6 ]TMU Research Center of Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei 11031, Taiwan
                [7 ]International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
                [8 ]TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan
                [9 ]Center for Reproductive Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan
                [10 ]Comprehensive Cancer Center of Taipei Medical University, Taipei 11031, Taiwan
                [11 ]PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
                Author notes
                [* ]Correspondence: cgmh3621@ 123456cgmh.org.tw (T.-S.C.); rita1204@ 123456tmu.edu.tw (Y.-H.H.); Tel.: +886-5-3621000 (ext. 2005) (T.-S.C.); +886-2-27361661 (ext. 3150) (Y.-H.H.)
                Author information
                https://orcid.org/0000-0002-4250-1722
                https://orcid.org/0000-0002-1581-6948
                https://orcid.org/0000-0001-6020-9998
                Article
                Publisher ID: ijms-22-01258
                DOI: 10.3390/ijms22031258
                PMC ID: 7865434
                PubMed ID: 33514004
                SO-VID: 4e1066c0-3148-4e1c-8653-8c94c5625dea
                Copyright © © 2021 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 30 December 2020
                Date accepted : 25 January 2021
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: metabolism,immuno-metabolism,metabolic reprogramming,immune checkpoint inhibitor,immunotherapy,resistance,tumor microenvironment,cancer niche
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: metabolism, immuno-metabolism, metabolic reprogramming, immune checkpoint inhibitor, immunotherapy, resistance, tumor microenvironment, cancer niche

                Comments

                Comment on this article

                scite_

                Similar content463

                See all similar

                Cited by11

                See all cited by

                Most referenced authors3,812

                See all reference authors