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      Elevated Serum Levels of 3-Deoxyglucosone, a Potent Protein-Cross-Linking Intermediate of the Maillard Reaction, in Uremic Patients

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          Abstract

          3-Deoxyglucosone (3-DG) has been identified as an intermediate of the Maillard reaction in vitro. We measured serum 3-DG levels using gas chromatography/ mass spectrometry and found a marked elevation in serum 3-DG levels in uremic patients compared with healthy subjects. The uremic patients with diabetes showed significantly higher serum concentrations of 3-DG than those without diabetes. 3-DG was demonstrated to be a potent protein-cross-linking agent in the reaction with lysozyme, leading to browning, fluorescence formation and polymerization of the protein by formation of advanced glycation end products (AGE). The increase in serum 3-DG levels in the uremic patients suggests that 3-DG may be responsible for the development of uremic complications by promoting the formation of AGE.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1995
          1995
          17 December 2008
          : 69
          : 4
          : 438-443
          Affiliations
          aDepartment of Internal Medicine, Nagoya University Branch Hospital, Nagoya, bFaculty of Pharmacy, Meijo University, Nagoya, cKureha Chemical Industry, Biomedical Research Laboratories, Tokyo, Japan
          Article
          188516 Nephron 1995;69:438–443
          10.1159/000188516
          7777110
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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