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      Maternal Betamethasone for Prevention of Respiratory Distress Syndrome in Neonates: Population Pharmacokinetic and Pharmacodynamic Approach

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          Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.

          Devender Roberts, Julie Brown, Nancy Medley … (2017)
          Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed.
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            A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.

            G C Liggins, R. Howie (1972)
            Article 0 comments Cited 213 times – based on 0 reviews     Review now
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              Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.

              Caroline Crowther, Christopher Jd McKinlay, Philippa Middleton … (2015)
              It has been unclear whether repeat dose(s) of prenatal corticosteroids are beneficial.
              Article 0 comments Cited 30 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Clinical Pharmacology & Therapeutics
                Abbreviated Title: Clin. Pharmacol. Ther.
                Publisher: Wiley
                ISSN (Print): 0009-9236
                ISSN (Electronic): 1532-6535
                Publication date Created: November 2020
                Publication date (Electronic): June 04 2020
                Publication date (Print): November 2020
                Volume: 108
                Issue: 5
                Pages: 1026-1035
                Affiliations
                [1 ]Pediatric and Perinatal Drug Evaluation and Pharmacology Université de Paris Paris France
                [2 ]URC/CIC Paris Descartes Necker Cochin Necker‐Enfants Malades Hospital Assistance Publique – Hôpitaux de Paris (AP‐HP) Paris France
                [3 ]CIC‐1419 Inserm, Cochin‐Necker Paris France
                [4 ]Clinical Pharmacology Department AP‐HP Paris Centre Hospital Group Paris France
                [5 ]Maternity Hôpital Necker – Enfants Malades AP‐HP Paris France
                [6 ]EA 7328 Paris Descartes University Sorbonne Paris Cité Paris France
                [7 ]Port‐Royal Maternity Unit Cochin Hospital AP‐HP Paris France
                [8 ]Obstetrical, Perinatal, and Pediatric Epidemiology Team and Biostatistics Sorbonne Paris Cité Research Center (U1153) INSERM and Université Paris Descartes Paris France
                [9 ]Department of Gynecology and Obstetrics Poissy‐Saint Germain Hospital Poissy France
                [10 ]EA 7285 Paris Saclay University Montigny‐Le‐Bretonneux France
                [11 ]Department of Obstetrics and Gynecology Trousseau Hospital AP‐HP Paris France
                [12 ]Department of Obstetrics and Gynecology Louis Mourier Hospital AP‐HP Colombes France
                [13 ]INSERM IAME UMR 1137 Université Paris Diderot Sorbonne Paris Cité Paris France
                [14 ]Université de Paris Neonatal Intensive Care Unit of Port‐Royal Paris Centre University Hospitals APHP Paris France
                [15 ]Université de Paris CRESS Obstetrical Perinatal and Pediatric Epidemiology Research Team EPOPé, INSERM, INRA Paris France
                Article
                DOI: 10.1002/cpt.1887
                PubMed ID: 32394434
                SO-VID: 50a7aebe-9c42-4e23-95eb-7759ba2a9b42
                Copyright © © 2020
                License:

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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