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      Active pharmaceutical ingredient (API) chemicals: a critical review of current biotechnological approaches

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          ABSTRACT

          The aim of this article was to generate a framework of bio-based economy by an effective utilization of biomass from the perspectives of agriculture for developing potential end bio-based products (e.g. pharmaceuticals, active pharmaceutical ingredients). Our discussion is also extended to the conservatory ways of bioenergy along with development of bio-based products and biofuels. This review article further showcased the fundamental principles for producing these by-products. Thereby, the necessity of creating these products is to be efficaciously utilization by small-scale farmers that can aid the local needs for bio-based materials and energy. Concurrently, the building up of small markets will open up the avenues and linkages for bigger markets. In nutshell, the aim of the review is to explore the pathway of the biotechnological approaches so that less chosen producers and underdeveloped areas can be allied so that pressure on the systems of biomass production can be relaxed.

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          Lignocellulosic biomass: a sustainable platform for the production of bio-based chemicals and polymers

          The ongoing research activities in the field of lignocellulosic biomass for production of value-added chemicals and polymers that can be utilized to replace petroleum-based materials are reviewed. The demand for petroleum dependent chemicals and materials has been increasing despite the dwindling of their fossil resources. As the dead-end of petroleum based industry has started to appear, today's modern society has to implement alternative energy and valuable chemical resources immediately. Owing to the importance of lignocellulosic biomass being the most abundant and bio-renewable biomass on earth, this critical review provides insights into the potential of lignocellulosic biomass as an alternative platform to fossil resources. In this context, over 200 value-added compounds, which can be derived from lignocellulosic biomass by various treatment methods, are presented with their references. Lignocellulosic biomass based polymers and their commercial importance are also reported mainly in the frame of these compounds. This review article aims to draw the map of lignocellulosic biomass derived chemicals and their synthetic polymers, and to reveal the scope of this map in today's modern chemical and polymer industry.
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            Global potential bioethanol production from wasted crops and crop residues

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              Emerging organic contaminants in groundwater: A review of sources, fate and occurrence.

              Emerging organic contaminants (EOCs) detected in groundwater may have adverse effects on human health and aquatic ecosystems. This paper reviews the existing occurrence data in groundwater for a range of EOCs including pharmaceutical, personal care, 'life-style' and selected industrial compounds. The main sources and pathways for organic EOCs in groundwater are reviewed, with occurrence data for EOCs in groundwater included from both targeted studies and broad reconnaissance surveys. Nanogram-microgram per litre concentrations are present in groundwater for a large range of EOCs as well as metabolites and transformation products and under certain conditions may pose a threat to freshwater bodies for decades due to relatively long groundwater residence times. In the coming decades, more of these EOCs are likely to have drinking water standards, environmental quality standards and/or groundwater threshold values defined, and therefore a better understanding of the spatial and temporal variation remains a priority. Copyright © 2012 Natural Environment Research Council. Published by Elsevier Ltd.. All rights reserved.
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                Author and article information

                Journal
                Bioengineered
                Bioengineered
                Bioengineered
                Taylor & Francis
                2165-5979
                2165-5987
                8 February 2022
                2022
                8 February 2022
                : 13
                : 2
                : 4309-4327
                Affiliations
                [a ]Fermentation Technology and Microbial Biotechnology Division, Csir- Indian Institute of Integrative Medicine (Csir-iiim); , J & K, India
                [b ]Academy of Scientific and Innovative Research (Acsir); , Ghaziabad-India
                [c ]Department of Foods and Nutrition, Government Home Science College, Affiliated to Panjab University; , Chandigarh, India
                [d ]Division of Infectious Disease Biology, Rajiv Gandhi Centre for Biotechnology; , - Trivandrum- India
                [e ]Deapartment of Food Technology, Tkm Institute of Technology; , Kollam-India
                [f ]Department of Resource and Environmental Science, College of Natural Resources and Environment, Northwest A&f University; , Shaanxi Province, Yangling, PR China
                [g ]Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary, Science and Technology (Csir-niist); , Trivandrum- India
                Author notes
                CONTACT Saurabh Saran ssaran@ 123456iiim.ac.in Fermentation Technology and Microbial Biotechnology Division, Csir- Indian Institute of Integrative Medicine (Csir-iiim); , Jammu-180001, J & K, India
                Author information
                https://orcid.org/0000-0002-9841-7343
                Article
                2031412
                10.1080/21655979.2022.2031412
                8973766
                35135435
                50add957-197f-4bc9-a933-3cad4606080c
                © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Figures: 3, Tables: 1, References: 149, Pages: 19
                Categories
                Review Article
                Review Article

                Biomedical engineering
                pharmaceutical ingredients,biotechnological approaches,challenges,future prospects

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