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      Evidence Basis for Ultrasound Guidance for Lower-Extremity Peripheral Nerve Block : Update 2016

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          Abstract

          This article reviews and summarizes randomized controlled studies that have investigated ultrasound guidance (USG) for lower-extremity peripheral nerve blocks in comparison with other peripheral nerve localization techniques and those that compared different ultrasound-guided techniques investigating optimal perineural local anesthetic distribution patterns.Thirty-four studies met the inclusion criteria (minimum Jadad score 3), and 10 additional studies directly compared USG with peripheral nerve stimulation, and 5 additional studies directly compared USG with landmark-based field blocks. Fourteen studies compared different local anesthetic distribution parameters.Analysis of the literature supports the use of USG for decreased block performance time, decreased block onset time, increased rate of complete sensory block, and increased analgesic efficacy. Ultrasound was never inferior to peripheral nerve stimulation. The research focus has evolved during the last 5 years into investigating optimal ultrasound-guided techniques.

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          Most cited references65

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          Ultrasound guidance reduces the risk of local anesthetic systemic toxicity following peripheral nerve blockade.

          Local anesthetic systemic toxicity (LAST) is a potentially life-threatening complication of local anesthetic administration. In this article, the results of the Australian and New Zealand Registry of Regional Anaesthesia were analyzed to determine if ultrasound-guided peripheral nerve blockade (PNB) was associated with a reduced risk of LAST compared with techniques not utilizing ultrasound technology.
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            Incidence of local anesthetic systemic toxicity and postoperative neurologic symptoms associated with 12,668 ultrasound-guided nerve blocks: an analysis from a prospective clinical registry.

            There are varying reports on the incidence of major morbidity associated with peripheral regional anesthesia. Our objective was to contribute to the knowledge regarding the incidence of local anesthetic systemic toxicity and postoperative neurologic symptoms in the setting of ultrasound-guided peripheral regional anesthesia. During an 8-year period, 12,668 patients undergoing peripheral regional anesthesia were evaluated. Using a clinical registry, incidence rates of postoperative neurologic symptoms, local anesthetic toxicity, pneumothorax, and vascular trauma were calculated. Univariate analysis was used to identify risk factors for postoperative neurologic symptoms. We defined postoperative neurologic symptoms as any sensory or motor dysfunction present for more than 5 days and anatomically consistent with the possibility of contribution from the nerve block. The incidence (per 1000 blocks) of adverse events across all peripheral regional anesthetics was 1.8 (95% confidence interval [CI], 1.1-2.7) for postoperative neurologic symptoms lasting longer than 5 days, 0.9 (95% CI, 0.5-1.7) for postoperative neurologic symptoms lasting longer than 6 months, 0.08 (95% CI, 0.0-0.3) for seizure, 0 (95% CI, 0-0.3) for pneumothorax, 0.6 (95% CI, 0.2-1.2) for unintended venous puncture, 1.2 (95% CI, 0.7-2.0) for unintended arterial puncture, and 2.0 (95% CI, 1.2-3.0) for patients having unintended paresthesia during block placement. There were no cardiac arrests. In the setting of a surgical procedure, ultrasound-guided regional anesthesia is associated with the risk of long-term postoperative neurologic symptoms. Local anesthetic systemic toxicity, however, is extremely uncommon.
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              Effects of ultrasound guidance on the minimum effective anaesthetic volume required to block the femoral nerve.

              We tested the hypothesis that ultrasound guidance may reduce the minimum effective anaesthetic volume (MEAV50) of ropivacaine 0.5% required to block the femoral nerve compared with nerve stimulation guidance. After standard premedication and sciatic nerve block were given, 60 patients undergoing knee arthroscopy were randomly allocated to receive a femoral nerve block with ropivacaine 0.5% using either nerve stimulation (group NS, n = 30) or ultrasound (group US, n = 30) guidance. The volume of the injected solution was varied for consecutive patients based on an up-and-down staircase method according to the response of the previous patient. The initial volume was 12 ml. A double-blinded observer evaluated the occurrence of complete loss of pinprick sensation in the femoral nerve distribution, with concomitant block of the quadriceps muscle: positive or negative responses within 30 min after the injection determined a 3 ml decrease or increase for the next patient, respectively. The mean (sd) MEAV50 for femoral nerve block was 15 (4) ml (95% CI, 7-23 ml) in group US and 26 (4) ml (95% CI, 19-33 ml) in group NS (P = 0.002). The effective dose in 95% of cases (ED95) calculated with probit transformation and logistic regression analysis was 22 ml (95% CI, 13-36 ml) in group US, and 41 ml (95% CI, fs 24-66 ml) in group NS. Ultrasound guidance provided a 42% reduction in the MEAV of ropivacaine 0.5% required to block the femoral nerve as compared with the nerve stimulation guidance.
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                Author and article information

                Journal
                Regional Anesthesia and Pain Medicine
                Regional Anesthesia and Pain Medicine
                Ovid Technologies (Wolters Kluwer Health)
                1098-7339
                2016
                2016
                : 41
                : 2
                : 261-274
                Article
                10.1097/AAP.0000000000000336
                26735152
                50ed935e-972d-4ce1-8509-0ae35c2653df
                © 2016
                History

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