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      Treadmill Exercise Protocols to Demonstrate Effectiveness of Nitrate Drugs in Relief of Angina Pectoris; Duration of Action and Degree of Functional Enhancement

      Cardiology

      S. Karger AG

      Treadmill, Nitroglycerin, Isosorbide dinitrate, Erythrityl tetranitrate

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          Abstract

          During constant uninterrupted exercise with mild angina present, either placebo, nitroglycerin, isosorbide dinitrate or erythrityl trinitrate was given by buccal membrane absorption. Placebo produced no relief and exercise had to be stopped. Nitroglycerin produced rapid complete relief and the long-acting drugs effected relief more slowly but of long duration as shown on repetitive walks as long as 3 h after drug administration.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-3437-6
          978-3-318-00026-9
          0008-6312
          1421-9751
          1981
          1981
          07 November 2008
          : 68
          : Suppl 2
          : 161-168
          Affiliations
          Director of Cardiac Rehabilitation, Centinela Hospital Medical Center, Inglewood, Calif., Clinical Professor of Medicine, University of California School of Medicine, Los Angeles, Calif., USA
          Article
          173332 Cardiology 1981;68:161–168
          10.1159/000173332
          6797734
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Drug Effect

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