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      Evaluation of endorphin content in the CSF of patients with trigeminal neuralgia before and after Gasserian ganglion thermocoagulation.

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          Abstract

          The beta-endorphin content in cerebrospinal fluid (CSF) was evaluated in 10 patients with idiopathic trigeminal neuralgia during medical treatment (with or without carbamazepine) and after selective thermocoagulation of the Gasserian ganglion. These values were compared with those obtained in a control group of seven patients without pain problems. No statistically significant difference was found between patients suffering from trigeminal neuralgia and those without pain. Furthermore, neither pharmacological treatment nor surgery changed CSF endorphin values. It is concluded that there is no pathogenetic relationship between trigeminal neuralgia and endorphins.

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          Author and article information

          Journal
          J. Neurosurg.
          Journal of neurosurgery
          Journal of Neurosurgery Publishing Group (JNSPG)
          0022-3085
          0022-3085
          Dec 1981
          : 55
          : 6
          Article
          10.3171/jns.1981.55.6.0935
          6170741

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