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      Incidencia de macrocefalia neonatal en el Hospital Cayetano Heredia, 2016 - 2017 Translated title: Incidence of neonatal macrocephaly at the Hospital Cayetano Heredia, 2016 - 2017

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          Abstract

          Objetivo: Determinar la incidencia de macrocefalia neonatal en un hospital de tercer nivel en Lima, Perú. Material y Métodos: Se definió macrocefalia en función al perÃmetro cefálico mayor que el percentil 97 para la edad y sexo. La información fue obtenida de los registros del Sistema Informático Perinatal del Hospital Cayetano Heredia durante el periodo 1º de enero, 2016 a 31 de diciembre, 2017. Se usó la Tabla Fenton para determinar los lÃmites de normalidad. Resultados: Se registraron 210 casos de macrocefalia neonatal y una tasa general de 26 por mil nacidos vivos, inversamente proporcional a la edad gestacional. Conclusiones: la macrocefalia es más frecuente en prematuros, con un factor de riesgo cinco veces mayor en este grupo poblacional.

          Translated abstract

          Objective: To determine the incidence of neonatal macrocephaly in a third level hospital from Lima, Perú. Methods: Macrocephaly was defined on the basis of a cephalic perimeter higher than the 97th percentile for age and sex. The report records of the Perinatal Computer System of Cayetano Heredia Hospital between January 1st., 2016 and December 31st, 2017 were used, as well as the Fenton growth chart to determine the limits of normality. Results: A total of 210 cases of neonatal macrocephaly was registered, a general rate of 26 per 1,000 live births. Neonatal macrocephaly incidence were inversely proportional to gestational age. Conclusions: Macrocephaly was higher in preterm neonates, with a risk factor five times higher in this population group.

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          Genetic disorders associated with macrocephaly.

          Adrian Williams, A J Dagli, Agatino Battaglia (2008)
          Macrocephaly is associated with many genetic disorders and is a frequent cause of referral to the clinical geneticist. In this review we classify the commonly encountered macrocephaly disorders into useful categories and summarize recent genetic advances. Conditions where macrocephaly is a predominant aspect of the clinical presentation are discussed and a diagnostic approach to the common macrocephaly disorders is provided. Some emphasis is placed on familial macrocephaly (sometimes referred to as benign external hydrocephalus) and on the macrocephaly associated with autism spectrum disorders. The more recent conditions associated with the leukodystrophies and the organic acidurias are reviewed, but the well known conditions involving storage disorders and bone dysplasias are mentioned but not discussed. The genetic macrocephaly conditions cover a broad spectrum of gene disorders and their related proteins have diverse biological functions. As of yet it is not clear what precise biological pathways lead to generalized brain overgrowth. Copyright 2008 Wiley-Liss, Inc.
          Article 0 comments Cited 33 times – based on 0 reviews     Review now
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            Macrocephaly: Solving the Diagnostic Dilemma.

            Ai Tan, Kshitij Mankad, Fabrício Gonçalves … (2018)
            Macrocephaly is a relatively common clinical condition affecting up to 5% of the pediatric population. It is defined as an abnormally large head with an occipitofrontal circumference greater than 2 standard deviations above the mean for a given age and sex. Megalencephaly refers exclusively to brain overgrowth exceeding twice the standard deviation. Macrocephaly can be isolated and benign or may be the first indication of an underlying congenital, genetic, or acquired disorder, whereas megalencephaly is more often syndromic. Megalencephaly can be divided into 2 subtypes: metabolic and developmental, caused by genetic defects in cellular metabolism and alterations in signaling pathways, respectively. Neuroimaging plays an important role in the evaluation of macrocephaly, especially in the metabolic subtype which may not be overtly apparent clinically. This article outlines the diverse etiologies of macrocephaly, delineates their clinical and radiographic features, and suggests a clinicoradiological algorithm for evaluation.
            Article 0 comments Cited 9 times – based on 0 reviews     Review now
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              Macrocephaly, increased intracranial pressure, and hydrocephalus in the infant and young child.

              A Vertinsky, Patrick D. Barnes (2007)
              Macrocephaly, increased intracranial pressure, and hydrocephalus are common related conditions that lead to cross-sectional imaging of the infant and young child. Imaging plays a central role in establishing the diagnosis and guiding disposition and treatment of these patients. In this review, a general overview is provided, and the more common causes of hydrocephalus are presented, including posthemorrhage, postinfection, developmental malformations, and masses. Imaging guidelines are also outlined for initial evaluation and follow-up, along with a discussion of the imaging features of shunt malfunction.
              Article 0 comments Cited 5 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): rnp
                Title: Revista de Neuro-Psiquiatría
                Abbreviated Title: Rev Neuropsiquiatr
                Publisher: Universidad Peruana Cayetano Heredia. Facultad de Medicina (Lima, , Peru )
                ISSN (Print): 0034-8597
                Publication date (Print and electronic): July 2019
                Volume: 82
                Issue: 3
                Pages: 197-201
                Affiliations
                [01] Lima orgnameUniversidad Peruana Cayetano Heredia Perú
                [02] Lima orgnameHospital Cayetano Heredia Perú
                Article
                Publisher ID: S0034-85972019000300006 Publisher ID: S0034-8597(19)08200300006
                DOI: 10.20453/rnp.v82i3.3573
                SO-VID: 53028775-0b5f-4529-b215-b2d11b47e490
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                Date received : 14 July 2019
                Date accepted : 05 September 2019
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 9, Pages: 5
                Product

                SciELO Peru

                Categories
                Subject: Artículos originales

                Keywords: incidencia,preterm,incidence,neonate,macrocephaly,pretérmino,Macrocefalia,neonato
                Data availability:
                Keywords: incidencia, preterm, incidence, neonate, macrocephaly, pretérmino, Macrocefalia, neonato

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