5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Effect of fibrin glue and opsite on open wounds in DB/DB mice.

      1 , , ,

      The Journal of surgical research

      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Fibrin glue is a hemostatic and adhesive agent that has been used for many years in Europe. It is made by the simultaneous mixing of concentrated fibrinogen complex and bovine thrombin reconstituted in a solution of calcium chloride. Upon mixing, the final stages of the coagulation cascade are mimicked, resulting in formation of a fibrin clot. Fibrin is vital in wound healing because the network formed in the wound acts not only as a hemostatic barrier but also as a scaffold for migrating cells. In this study, fibrin glue (60 mg/ml) was applied on 6-mm-diameter circular full-thickness wounds in homozygous, genetically diabetic mice. Results showed delayed wound closure as compared to paired control wounds. Dilution of the protein concentration of fibrin glue to 1 mg/ml resulted in higher histological scores compared to those for wounds treated with 60 mg/ml fibrin glue. Finally, the application of an adherent semipermeable dressing (Opsite) over the wound per se resulted in delayed wound closure. Delayed closure may be due either to mechanical obstruction to the migration or proliferation of cells that actively participate in the wound healing process, mechanical inhibition of wound contraction, or both.

          Related collections

          Author and article information

          Journal
          J. Surg. Res.
          The Journal of surgical research
          Elsevier BV
          0022-4804
          0022-4804
          Mar 1993
          : 54
          : 3
          Affiliations
          [1 ] Holland Laboratory, American Red Cross, Rockville, Maryland 20855.
          Article
          S0022-4804(83)71032-2
          10.1006/jsre.1993.1032
          8474236

          Comments

          Comment on this article