Association of plasma xanthine oxidoreductase activity with severity and clinical outcome in patients with chronic heart failure.

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Abstract

Oxidative stress due to purine degradation is associated with the development of chronic heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine degradation that plays a key role in uric acid (UA) production with a resultant increase in reactive oxygen species. However, the relationship between plasma XOR activity and CHF severity and clinical outcome remains unclear.

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Author and article information

Journal

Journal ID (iso-abbrev): Int. J. Cardiol.

Title: International journal of cardiology

Publisher: Elsevier BV

ISSN (Electronic): 1874-1754

ISSN (Print): 0167-5273

Publication date (Electronic): Feb 01 2017

Volume: 228

Affiliations

[1 ] Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.

[2 ] Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan. Electronic address: tewatana@med.id.yamagata-u.ac.jp.

[3 ] Radioisotope and Chemical Analysis Center, Laboratory Management Department, Sanwa Kagaku Kenkyusho Co., Ltd., Mie, Japan.

[4 ] Pharmacological Study Group, Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., Mie, Japan.

Article

Publisher Item ID: S0167-5273(16)33523-9

DOI: 10.1016/j.ijcard.2016.11.077

PubMed ID: 27865177

SO-VID: 54207075-2f04-4e1b-8ab3-0a7e1b081077

History

Keywords: Cardiac prognosis,Heart failure,Uric acid,Xanthine oxidoreductase

Data availability:

Keywords: Cardiac prognosis, Heart failure, Uric acid, Xanthine oxidoreductase

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