+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effect of Age and Sex on Residual Stress in the Aorta

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          When ring segments of artery free of external loads are cut longitudinally, they spring open. This property, which has been termed residual strain, is a manifestation of an underlying residual stress and may be quantified by measuring the degree to which the cut ring springs open. Residual stress serves to redistribute the forces in the media and to minimize the stress gradient between its inner and outer margins. Its magnitude and distribution are closely related to vascular growth and development. We have measured the degree of opening (in terms of an opening angle, see below for its definition) in 168 rings removed from six positions along aortae obtained at autopsy from 30 subjects aged between 3 months and 87 years. At all ages, there was an overall increase in opening angle along the aorta away from the heart. At all positions, the opening angle increased with age and was higher in vessels with visible atheroma. At all ages, the opening angle was significantly greater in males than in females. This difference persisted when allowance was made for the greater incidence of atheroma in males. We have found a similar age-related increase in rats, although there was no difference between males and females. These observations are consistent with a recently proposed ‘stress-growth’ law in which remodelling of the arterial wall is driven by the non-uniform distribution of stress across it and may be associated with known sex-related differences in the aetiology of cardiovascular disease.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          24 September 2008
          : 32
          : 6
          : 398-405
          Department of Morbid Anatomy, London Hospital Medical College, London, UK
          159115 J Vasc Res 1995;32:398–405
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Research Paper


          Comment on this article