Analysis of radioligand binding experiments

McPherson, Grant A.

doi:10.1016/0160-5402(85)90034-8

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Analysis of radioligand binding experiments

Author(s): Grant A. McPherson

Publication date Created: November 1985

Publication date (Print): November 1985

Journal: Journal of Pharmacological Methods

Publisher: Elsevier BV

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Most cited references 6

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Ligand: a versatile computerized approach for characterization of ligand-binding systems.

P Munson, D Rodbard (1980)

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Numbers of receptor sites from Scatchard graphs: facts and fantasies.

I Klotz (1982)

Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.