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      Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex.

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      Nature

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          Abstract

          Lithium is a unique drug with therapeutic as well as prophylactic value for both manic and depressive phases of manic-depressive illness. The precise mechanisms of its clinical efficacy remain unknown, but there are two main theories of its biochemical action. One proposes that lithium inhibits adrenergically activated adenylate cyclase function whereas the other suggests that it inhibits phosphatidyl inositol turnover, which is known to be activated by cholinergic agonists. Neither mechanism alone, however, can explain both the antimanic and antidepressant effects of lithium. Because of the pivotal role of G proteins in post-receptor information transduction, we have investigated the interaction of lithium with G protein function. Lithium at therapeutically efficacious concentrations completely blocked both adrenergic and cholinergic agonist-induced increases in [3H]GTP binding to membranes from rat cerebral cortex, in both in vitro and ex vivo experiments. The same lithium treatments also abolished guanine nucleotide modulation of agonist binding. Our findings suggest G proteins (Gs and Gi or Go) as the molecular site of action for both the antimanic and antidepressant effects of lithium.

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          Author and article information

          Journal
          Nature
          Nature
          0028-0836
          0028-0836
          Feb 4 1988
          : 331
          : 6155
          Affiliations
          [1 ] Clinical Pharmacology Unit, Ben Gurion University of the Negev, Beer Sheva, Israel.
          Article
          10.1038/331440a0
          3340189

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