Association of 49245A>G (rs868) polymorphism in the 3'UTR of donor TGFBR1 gene with course of hepatitis C following orthotopic liver transplantation.

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Abstract

Terminal hepatitis C is one of the leading indications for orthotopic liver transplantation (OLT). However, hepatitis C virus (HCV) reinfection occurs in almost all recipients and usually leads to progressive fibrosis and graft failure. Transforming growth factor-b (TGF-β) plays a part in transplanted liver cirrhosis, but nothing is known about the possible role of genetic diversity of TGF-β receptor system. Therefore, the aim of our study was to investigate whether genetic variation in 3' untranslated region (3'UTR) of TGF-β receptor type I (TGFBR1) gene is associated with recurrence and severity of hepatitis C and liver fibrosis following OLT in HCV-infected patients.

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Journal

Journal ID (iso-abbrev): Ann. Transplant.

Title: Annals of transplantation

Publisher: International Scientific Information, Inc.

ISSN (Electronic): 2329-0358

ISSN (Print): 1425-9524

Publication date (Electronic): Dec 12 2014

Volume: 19

Affiliations

[1 ] Department of Pathology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.

[2 ] Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.

[3 ] Department of Immunology, Transplantology and Internal Medicine, Institute of Transplantology, Medical University of Warsaw, Warsaw, Poland.

[4 ] Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.

[5 ] Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

[6 ] Department of Medical Genetics, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.

Article

Publisher Item ID: 891119

DOI: 10.12659/AOT.891119

PubMed ID: 25502482

SO-VID: 5554dd88-d2bd-4477-9920-6a93d052d69b

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